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Name Index P

• PF-06282999 (Catalog# : 020102, Cas# : 1435467-37-0)PF-06282999 is an irreversible inactivator of myeloperoxidase, and currently in clinical trials for the potential treatment of cardiovascular diseases.
• PF-3274167 (Catalog# : 020101, Cas# : 900510-03-4)PF-3274167 is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM.
• Pifithrin-alpha (Catalog# : 012011, Cas# : 63208-82-2)Pifithrin- is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.
• PF-04880594 (Catalog# : 012008, Cas# : 1111636-35-1)PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia.
• PF-2545920 (Catalog# : 012006, Cas# : 898562-94-2)PF-2545920 is a phosphodiesterase inhibitor selective for the PDE10A subtype, which is potentially useful for the treatment of schizophrenia.
• Pyriofenone (Catalog# : 011119, Cas# : 688046-61-9)Coming soon!
• PF-03814735 (Catalog# : 011105, Cas# : 942487-16-3)PF-03814735 is an orally bioavailable, ATP-competitive, reversible small-molecule Aurora kinase inhibitor with potential antineoplastic activity.
• PND-1186 (Catalog# : 010821, Cas# : 1061353-68-1)PND-1186 is a potent FAK inhibitor with a 50% inhibitory concentration of 1.5 nM in vitro.
• PF-04217903 (Catalog# : 010807, Cas# : 956905-27-4)PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations.
• PF-5274857 (Catalog# : 010423, Cas# : 1373615-35-0)PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the bloo
• Progesterone (Catalog# : 010416, Cas# : 57-83-0)Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
• Pravadoline (Catalog# : 010415, Cas# : 92623-83-1)Coming soon!
• PD318088 (Catalog# : 010414, Cas# : 391210-00-7)PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.
• PF-04691502 (Catalog# : 123020, Cas# : 1013101-36-4)PF-04691502 is an ATP-competitive PI3K(///)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ER
• PKC412 (Catalog# : 123013, Cas# : 120685-11-2)PKC412 is a broad spectrum protein kinase inhibitor; inhibits conventional PKC isoforms (, , ), PDFR, VEGFR2, Syk, PKC, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and
• Plerixafor octahydrochloride (Catalog# : 123004, Cas# : 155148-31-5)Plerixafor octahydrochloride is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively.
• PF-3084014 (Catalog# : 122950, Cas# : 1290543-63-3)PF-3084014 is a novel -secretase inhibitor that reduces amyloid-beta (Abeta) production with an in vitro IC(50) of 1.2 nM (whole-cell assay) to 6.2 nM (cell-free assay).
• Pacritinib(SB1518) (Catalog# : 122941, Cas# : 937272-79-2)Pacritinib (puh-CRIT-i-nib) is an oral tyrosine kinase inhibitor (TKI) with activity against two important activating mutations: Janus Associated Kinase 2 (JAK2) and FMS-like tyr
• PHA-848125 (Catalog# : 122916, Cas# : 802539-81-7)PHA-848125 is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM; >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7.
• PI-3065 (Catalog# : 122908, Cas# : 955977-50-1)PI-3065 is a novel potent and selective PI3K p110 inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110, p110, p110, DNA-PK and mTOR.
• PD 123319 (Catalog# : 122903, Cas# : 130663-39-7)PD 123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
• PNU-282987 (Catalog# : 122827, Cas# : 123464-89-1)PNU-282987 is a selective 7 nicotinic acetylcholine receptor(7 nAChR) agonist with Ki of 26 nM; no affinity for 11æ and 34 nAChRs (IC50 60 M).
• PF-431396 (Catalog# : 122818, Cas# : 717906-29-1)PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively), PF-431396 has a Kd value of 445 nM f
• Posaconazole (Catalog# : 122815, Cas# : 171228-49-2)Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
• PQ401 (Catalog# : 122806, Cas# : 196868-63-0)PQ401, a selective insulin-like growth factor-1 receptor blocker, is a novel diarylurea compound that inhibits IGF1R autophosphorylation with IC50 < 1 uM.
• Pardoprunox (Catalog# : 122523, Cas# : 269718-84-5)Pardoprunox is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist.
• PKC-IN-1 (Catalog# : 122520, Cas# : 1046787-18-1)PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM; compound example H6 from patent WO 2008096260 A1.
• PF-04447943 (Catalog# : 122515, Cas# : 1082744-20-4)PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9
• PD-0325901 (Catalog# : 122405, Cas# : 391210-10-9)PD-0325901 i a potent bioavailable and selective MEK inhibitor, which targets mitogen-activated protein kinase kinase with potential antineoplastic activity.
• P005672 hydrochloride (Catalog# : 122302, Cas# : 1035979-44-2)P005672 hydrochloride is used for antibacterial/anti-inflammatory acne treatment.