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• Pimecrolimus (Catalog# : 81302, Cas# : 137071-32-0)Pimecrolimus is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.
• Pitavastatin Calcium (Catalog# : 81301, Cas# : 147526-32-7)Pitavastatin is a member of the blood cholesterol lowering medication class of statins, which is an inhibitor of HMG-CoA reductase, the enzyme that catalyses the first step of ch
• PKI-587 (Catalog# : 73109, Cas# : 1197160-78-3)PKI-587 is a potent inhibitor to PI3K-, PI3K-, and mTOR (FRAP) with IC50 of 0.4 nM, 5.4 nM, and 1.6 nM, respectively. PKI-587 also exhibits potency against the most frequently oc
• PFK-015 (Catalog# : 52824, Cas# : 4382-63-2)PFK-015 is an effective inhibitor of PFKFB3 with IC50 of 110 nM (recombinant PFKFB3) and inhibits PFKFB3 activity in cancer cells with IC50 of 20 nM.
• Pramiracetam (Catalog# : 52817, Cas# : 68497-62-1)Pramiracetam is a nootropic drug derived from piracetam, and is more potent. Pramiracetam reportedly improved cognitive deficits associated with traumatic brain injuries.
• PF-573228 (Catalog# : 52816, Cas# : 869288-64-2)PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for inhibiton of purified recombinant catalytic fragment of FAK; inhibits FAK phosphorylation on Tyr(397) with
• Paromomycin Sulfate (Catalog# : 52815, Cas# : 1263-89-4)Paromomycin Sulfate is an aminoglycoside antibiotics inhibiting protein synthesis in non-resistant cells by binding to 16S ribosomal RNA
• PLX647 (Catalog# : 52756, Cas# : 873786-09-5)PLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively
• Pexidartinib (Catalog# : 52753, Cas# : 1029044-16-3)pexidartinib is acapsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Pexidarti
• PF-543 (Catalog# : 52740, Cas# : 1415562-82-1)PF-543 is a novel cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
• PSI-7977 (Catalog# : 52718, Cas# : 1190307-88-0)PSI-7977(sofosbuvir) is an investigational nucleotide analog for treatment of chronic HCV infection.
• Pirfenidone (Catalog# : 52701, Cas# : 53179-13-8)Pirfenidone(AMR69) is an inhibitor for TGF- production and TGF- stimulated collagen production, reduces production of TNF- and IL-1, and also has anti-fibrotic and anti-inflammat
• Poziotinib (Catalog# : 52634, Cas# : 1092364-38-9)Poziotinib(NOV120101; HM781-36B) is an irreversible Pan-HER inhibitor with IC50s of 3/5/23 nM for HER1/HER2/HER4 respectively
• PF-4708671 (Catalog# : 52631, Cas# : 1255517-76-0)PF-4708671 is a novel cell-permeable inhibitor of S6K1 (p70 ribosomal S6 kinase 1), with a Ki of 20 nM and IC50 of 160 nM.
• Perifosine (Catalog# : 52613, Cas# : 157716-52-4)Perifosine (KRX-0401; D-21266; NSC 639966) is a novel Akt inhibitor with IC50 of 4.7 M, targets pleckstrin homology domain of Akt.
• Plinabulin (Catalog# : 52603, Cas# : 714272-27-2)Plinabulin (NPI-2358) is a vascular disrupting agents (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells
• PLX-4720 (Catalog# : 52592, Cas# : 918505-84-7)PLX 4720 is a potent and selective inhibitor of B-RafV600E(IC50=13 nM) and c-Raf-1Y340D/Y341D(IC50=6.7 nM); 10-fold selectivity for B-RafV600E than wild-type B-Raf.
• Palomid 529 (Catalog# : 52591, Cas# : 914913-88-5)Palomid 529 (P529) is a novel potent inhibitor of both the mTORC1 and mTORC2 complexes with a GI50 of<35 M in the NCI-60 cell lines panel; reduces phosphorylation of pAktS473,
• PHT-427 (Catalog# : 52583, Cas# : 1191951-57-1)PHT-427 is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with Ki of 2.7 M and 5.2 M, respectively.
• Purvalanol A (Catalog# : 52564, Cas# : 212844-53-6)Purvalanol A(NG-60) is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/
• PI3K-IN-1 (Catalog# : 52560, Cas# : 1349796-36-6)PI3K-IN-1 is a potent inhibitor of PI3K, more information can be found in patent WO2012103524 A2 and WO2013147649 A2.
• Purvalanol B (Catalog# : 52559, Cas# : 212844-54-7)Purvalanol B(NG-95) is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and
• Pracinostat (Catalog# : 52552, Cas# : 929016-96-6)Pracinostat(SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6; has no activity against the class III isoenzyme SIRT I.
• Purmorphamine (Catalog# : 52519, Cas# : 483367-10-8)Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 M and also is an inducer of osteoblast differentiation w
• PD 169316 (Catalog# : 52513, Cas# : 152121-53-4)PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM).
• 2,4-Pyrimidinediamine with linker (Catalog# : 52214, Cas# : 1430089-64-7)2,4-Pyrimidinediamine with linker is a patent compound in WO2013055780A1, Page 71; multikinase inhibitor and has a -NH2 terminal linker for further synthesis.
• PD153035 (Catalog# : 52223, Cas# : 153436-54-5)PD153035(ZM 252868; AG 1517) is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect against PGDFR, FGFR, CSF-1, InsR and Src.
• PPQ-102 (Catalog# : 52233, Cas# : 931706-15-9)PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC 50approximately 90 nM.
• PTC124c (Catalog# : 52231, Cas# : 775304-57-9)PTC124 (Ataluren) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 M, may provide treatment for genetic disorders cause
• PR-619 (Catalog# : 52227, Cas# : 2645-32-1)PR-619 is a broad-range DUB inhibitor with potential for further development as a chemotherapeutic agent in cancer therapy