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3PO

Catalog No.: 161227109
Cas No.: 13309-08-5
Purity : 98% 
161227109 - 3PO | CAS 13309-08-5

Catalog number : 161227109

CAS number : 13309-08-5

Molecular Formula : C13H10N2O 

Molecular Weight : 210.236 

Iupac Chemical Name : 3PO 

Smile : c1cc(cnc1)/C=C/C(=O)c2ccncc2

InChiKey : UOWGYMNWMDNSTL-ONEGZZNKSA-N

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SynonymsN/A 
Molecular FormulaC13H10N2O 
Molecular Weight210.236 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Smilec1cc(cnc1)/C=C/C(=O)c2ccncc2
InChiKeyUOWGYMNWMDNSTL-ONEGZZNKSA-N
InChiInChI=1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+
MDLMFCD00224002
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3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor. 3PO reduces glycolytic flux and suppresses glucose uptake. 3PO may be useful agents in combination with other drugs that inhibit cancer cell proliferation. PFKFB3 inhibitors suppress glucose uptake, which in turn causes an increase in autophagy. The addition of selective inhibitors of autophagy to 3PO and its more potent derivatives may prove useful as rational combinations for the treatment of cancer. 

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