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PCI-34051

Catalog No.: 17022402
Cas No.: 950762-95-5
Purity : 98% 
17022402 - PCI-34051 | CAS 950762-95-5

Catalog number : 17022402

CAS number : 950762-95-5

Molecular Formula : C17H16N2O3 

Molecular Weight : 296.32 

Iupac Chemical Name : PCI-34051 

Smile : COc1ccc(cc1)Cn2ccc3c2cc(cc3)C(=O)NO

InChiKey : AJRGHIGYPXNABY-UHFFFAOYSA-N

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SynonymsPCI34051; PCI 34051; PCI34051 
Molecular FormulaC17H16N2O3 
Molecular Weight296.32 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCOc1ccc(cc1)Cn2ccc3c2cc(cc3)C(=O)NO
InChiKeyAJRGHIGYPXNABY-UHFFFAOYSA-N
InChiInChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10,21H,11H2,1H3,(H,18,20)
MDLMFCD11114393
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PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor with >200-fold selectivity over the other HDAC isoforms. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. Unlike broad-spectrum HDAC inhibitors, PCI-34051 does not cause detectable histone or tubulin acetylation. PCI-34051 could offer benefits including a greater therapeutic index for treating T-cell malignancies. 

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