PCI-34051
Catalog No: 17022402
CAS Number: 950762-95-5
Purity: 98%
PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor with >200-fold selectivity over the other HDAC isoforms. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. Unlike broad-spectrum HDAC inhibitors, PCI-34051 does not cause detectable histone or tubulin acetylation. PCI-34051 could offer benefits including a greater therapeutic index for treating T-cell malignancies.
For research use only. We do not sell to patients.
Chemical Information
| Name | PCI-34051 |
|---|---|
| Iupac Chemical Name | PCI-34051 |
| Synonyms | PCI34051; PCI 34051; PCI34051 |
| Molecular Formula | C17H16N2O3 |
| Molecular Weight | 296.32 |
| Smile | COc1ccc(cc1)Cn2ccc3c2cc(cc3)C(=O)NO |
| InChiKey | AJRGHIGYPXNABY-UHFFFAOYSA-N |
| InChi | InChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10,21H,11H2,1H3,(H,18,20) |
| CAS Number | 950762-95-5 |
| MDL | MFCD11114393 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
