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• PIK-75 (Catalog# : 17030913, Cas# : 372196-67-3)PIK-75 was developed as part of a PI 3-kinase drug discovery program. PIK75 attenuates insulin stimulation of Akt/PKB in a range of cell types at 100 nM.
• PF-05089771 (Catalog# : 17030912, Cas# : 1235403-62-9)PF-05089771 is a Selective Nav1.7 Inhibitor (IC50 = 11 nM) that interacts with the voltage-sensor domain (VSD) of domain IV. PF-05089771 exhibits a slow onset of block that is de
• PF-CBP1 (Catalog# : 17030716)PF-CBP1, also known as PF-06670910, is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophage
• Piperoxan HCl (Catalog# : 17030708, Cas# : 135-87-5)Piperoxan, also known as benodaine, is a drug which was the very first antihistamine to be discovered. This compound, derived from benzodioxan, was prepared in the early 1930s by
• PFI-1 (Catalog# : 17030704, Cas# : 1403764-72-6)PFI-1 is a potent and highly selective protein interaction Inhibitor, which targets BET bromodomain. PFI-1 that efficiently blocks the interaction of BET BRDs with acetylated his
• Pirmenol (Catalog# : 17030702, Cas# : 68252-19-7)Pirmenol is an antiarrhythmic agent. Pirmenol inhibits muscarinic acetylcholine receptor-operated K+ current in the guinea pig heart. Pirmenol is active in a variety of experimen
• Ponatinib HCl (Catalog# : 17030607, Cas# : 1114544-31-8)Ponatinib, also known as AP24534 is an oral drug for the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosomeCpositive (Ph+) acute lymphoblastic leukemia (ALL)
• PD-161570 (Catalog# : 17030304, Cas# : 192705-80-9)PD-161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). PD 161570 had about 5- and 100-fold greater selectivity towar
• PF-06273340 (Catalog# : 17030201, Cas# : 1402438-74-7)PF-06273340 is a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor with an excellent LipE profile (IC50 value: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-062733
• PF-8380 (Catalog# : 17030115, Cas# : 1144035-53-9)PF-8380 is a potent autotaxin inhibitor with an IC(50) of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. PF-8380 has adequate oral bioavailability and exposures
• Pleconaril (Catalog# : 17030111, Cas# : 153168-05-9)Pleconaril is an antiviral drug potentially for the treatment of enterovirus infection and asthma. Pleconaril, administered either orally or intranasally, is active against virus
• Panobinostat (Catalog# : 17022809, Cas# : 404950-80-7)Panobinostat(LBH-589) is a broad-spectrum HDAC inhibitor; low nanomolar concentrations (IC50=5-20 nM) of LBH589 induced cell-cycle arrest, apoptosis, and histone (H3K9 and H4K8)
• Pelitinib (Catalog# : 17022702, Cas# : 257933-82-7)Pelitinib (EKB-569; WAY-EKB 569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM. Pelitinib displays much higher inhibitory activity against EGFR, compared with th
• PCI-34051 (Catalog# : 17022402, Cas# : 950762-95-5)PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor with >200-fold selectivity over the other HDAC isoforms. PCI-34051 induces caspase-dependent apoptosis in
• Psoralen (Catalog# : 17021307, Cas# : 66-97-7)Psoralen is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen inhibits the proliferation of MCF-7/ADR cells as
• P7C3-A20 (Catalog# : 16122838, Cas# : 1235481-90-9)P7C3-A20 is an analogue of P7C3, and is a proneurogenic, neuroprotective agent. P7C3-A20 displayed increased activity and an improved toxicity profile compared to P7C3. P7C3-A20
• P7C3 (Catalog# : 16122837, Cas# : 301353-96-8)P7C3 is a proneurogenic, neuroprotective agent. P7C3 protects newborn neurons from apoptotic cell death, and promotes neurogenesis in mice and rats in the subgranular zone of the
• 3PO (Catalog# : 161227109, Cas# : 13309-08-5)3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor. 3PO reduces glycolytic flux and suppresses glucose uptake. 3PO may be useful agents in combinati
• Perampanel (Catalog# : 161227104, Cas# : 380917-97-5)Perampanel is an orally active, non-competitive, and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist, with anti-epileptic
• P5091 (P005091) (Catalog# : 16122795, Cas# : 882257-11-6)P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 M and the closely related USP47.P5091 is a trisubstituted thiophene wi
• PYR-41 (Catalog# : 16122793, Cas# : 418805-02-4)PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.PYR-41 (50 M) inhibits activity of ubiquitin-activating enzyme E1 by over 9
• PRI-724 (Catalog# : 16122785, Cas# : 847591-62-2)PRI-724 is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. PRI-724 specifically inhibits the recr
• PLX7904 (Catalog# : 16122777, Cas# : 1393465-84-3)PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but doe
• Pamapimod (R-1503, Ro4402257) (Catalog# : 16122774, Cas# : 449811-01-2)Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38 and p38 enzymatic activity with IC50 values of 0.0140.002 a
• PRIMA-1 (Catalog# : 16122770, Cas# : 5608-24-2)PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
• Picolinamide (Catalog# : 16122714, Cas# : 1452-77-3)Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
• PD0166285 (Catalog# : 16122710, Cas# : 185039-89-8)PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.PD0166285 is identified to inhibit Wee1 activ
• Peficitinib (ASP015K, JNJ-54781532) (Catalog# : 16122707, Cas# : 944118-01-8)Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.ASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than
• PF-543 Citrate (Catalog# : 6111525, Cas# : 1415562-83-2)PF-543 Citrate is a novel cell-permeant inhibitor of SphK1 with a K(i) of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 i
• Pasireotide (Catalog# : 61115, Cas# : 396091-73-9)Pasireotide(SOM 230) is a stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.