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MAPK
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Metabolic Enzyme/Protease
Neuronal Signaling
NF-κB
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+86-17702719238
sales@sun-shinechem.com
Home
Inhibitors&Agonists
Angiogenesis
Anti-infection
Apoptosis
Autophagy
Cell Cycle
Cytoskeleton
DNA Damage
Epigenetics
GPCR & G Protein
Immunology & Inflammation
JAK/STAT
MAPK
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Neuronal Signaling
NF-κB
Protein Tyrosine Kinase
PI3K/Akt/mTOR
Stem Cells & Wnt
TGF-beta/Smad
Ubiquitin
Vitamin D Related
PROTAC
Antibody-drug Conjugate/ADC Related
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Name Index P
PF-4708671
(Catalog# : 52631, Cas# :
1255517-76-0
)
PF-4708671 is a novel cell-permeable inhibitor of S6K1 (p70 ribosomal S6 kinase 1), w
Perifosine
(Catalog# : 52613, Cas# :
157716-52-4
)
Perifosine (KRX-0401; D-21266; NSC 639966) is a novel Akt inhibitor with IC50 of 4.7
Plinabulin
(Catalog# : 52603, Cas# :
714272-27-2
)
Plinabulin (NPI-2358) is a vascular disrupting agents (VDA) against tubulin-depolymer
PLX-4720
(Catalog# : 52592, Cas# :
918505-84-7
)
PLX 4720 is a potent and selective inhibitor of B-RafV600E(IC50=13 nM) and c-Raf-1Y34
Palomid 529
(Catalog# : 52591, Cas# :
914913-88-5
)
Palomid 529 (P529) is a novel potent inhibitor of both the mTORC1 and mTORC2 complexe
PHT-427
(Catalog# : 52583, Cas# :
1191951-57-1
)
PHT-427 is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains o
Purvalanol A
(Catalog# : 52564, Cas# :
212844-53-6
)
Purvalanol A(NG-60) is a potent, cell-permeable, and selective inhibitor of cyclin-de
PI3K-IN-1
(Catalog# : 52560, Cas# :
1349796-36-6
)
PI3K-IN-1 is a potent inhibitor of PI3K, more information can be found in patent WO20
Purvalanol B
(Catalog# : 52559, Cas# :
212844-54-7
)
Purvalanol B(NG-95) is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6,
Pracinostat
(Catalog# : 52552, Cas# :
929016-96-6
)
Pracinostat(SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with excepti
Purmorphamine
(Catalog# : 52519, Cas# :
483367-10-8
)
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopami
PD 169316
(Catalog# : 52513, Cas# :
152121-53-4
)
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 =
PD153035
(Catalog# : 52223, Cas# :
153436-54-5
)
PD153035(ZM 252868; AG 1517) is a potent and specific inhibitor of EGFR with Ki and I
PPQ-102
(Catalog# : 52233, Cas# :
931706-15-9
)
PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride curre
PTC124c
(Catalog# : 52231, Cas# :
775304-57-9
)
PTC124 (Ataluren) selectively induces ribosomal read-through of premature but not nor
PR-619
(Catalog# : 52227, Cas# :
2645-32-1
)
PR-619 is a broad-range DUB inhibitor with potential for further development as a che
PFI-2
(Catalog# : 52113, Cas# :
1627676-59-8
)
PFI-2 is a potent, selective, and cell-activelysine methyltransferase SETD7inhibitor
Ponatinib (AP24534)
(Catalog# : 52107, Cas# :
943319-70-8
)
Ponatinib (AP24534) is a novel, potent multi-target inhibitor ofAbl, PDGFR, VEGFR2, F
Palbociclib
(Catalog# : 52001, Cas# :
571190-30-2
)
Palbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-depen
Palbociclib(PD-0332991)HCl
(Catalog# : 52011, Cas# :
827022-32-2
)
Palbociclib (PD-0332991) HCl is a highly selective inhibitor ofCDK4/6withIC50of 11 nM
Palbociclib (PD0332991) Isethionate
(Catalog# : 52012, Cas# :
827022-33-3
)
Palbociclib (PD0332991) Isethionate is a highly selective inhibitor ofCDK4/6withIC50o
PF-06463922
(Catalog# : 51701, Cas# :
1454846-35-5
)
PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosin
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Products Catalog
Signaling Pathway
-- Angiogenesis
----
VEGFR
----
JAK
----
EGFR
----
PDGFR
----
FLT3
----
FGFR
----
Src
----
ALK
----
Syk
----
HIF
-- Anti-infection
----
CMV
----
Filovirus
----
HBV
----
HCV
----
HIV
----
HSV
----
Influenza Virus
----
RSV
----
SARS-CoV
----
Antibacterial
----
Antifungal
----
Parasite
-- Apoptosis
----
PD-1
----
PD-L1
----
Bcl-2
----
Caspase
----
TNF-alpha
----
Survivin
----
IAP
----
PERK
----
p53
----
Mdm2
----
E1/E2/E3 Enzyme
-- Autophagy
----
LRRK2
----
CXCR
----
Autophagy
-- Cell Cycle
----
CDK
----
PD-1
----
PD-L1
----
Chk
----
ROCK
----
PLK
----
APC
----
Wee1
----
DYRK
----
c-Myc
----
Aurora Kinase
----
ROCK inhibitor
----
Eukaryotic Initiation Factor (eIF)
----
NEKs
-- Cytoskeleton
----
HSP
----
Kinesin
----
Integrin
----
Dynamin
----
Wnt
----
β-catenin
----
Gap Junction Protein
-- DNA Damage
----
PARP
----
DNA/RNA Synthesis
----
Sirtuin
----
Topoisomerase
----
DNA-PK
----
Telomerase
----
RAD51
----
HDAC
----
ATM
----
DNA alkylator
----
Mps1
-- Epigenetics
----
PARP
----
JAK
----
Pim
----
PKC
----
PKD
----
Sirtuin
----
Histone Demethylase
----
Histone Acetyltransferase
----
HDAC
----
HIF-PH
----
Aurora Kinase
----
Histone Methyltransferase
----
METTL3
----
Epigenetic Reader Domain
----
Methionine Adenosyltransferase (MAT)
-- GPCR & G Protein
----
Histamine Receptor
----
Dopamine Receptor
----
Opioid Receptor
----
Endothelin Receptor
----
SGLT
----
OX Receptor
----
CaSR
----
CXCR
----
Vasopressin Receptor
----
Glucagon Receptor
----
Prostaglandin Receptor
----
5-HT Receptor
----
Adrenergic Receptor
----
Cannabinoid Receptor
----
Sphingosine 1 Phosphate Receptor
----
PKA
----
Adenosine Receptor
----
GnRH
----
LPL Receptor
----
Ras
----
Cholecystokinin Receptor
----
Melanocortin Receptor
----
RXFP Receptor
----
Bradykinin Receptor
----
GLP Receptor
-- Immunology & Inflammation
----
PD-1
----
PD-L1
----
COX
----
CCR
----
Histamine Receptor
----
TLR
----
CXCR
----
MALT
----
TDO
----
NOS
----
IDO
----
Thrombopoietin Receptor(TPO)
----
NLR inhibitor
----
Interleukin Related
----
CD73
----
Complement System
----
Aryl Hydrocarbon Receptor
----
Kallikrein
----
IRAK
----
Reactive Oxygen Species(ROS)
----
SOD
-- JAK/STAT
----
JAK
----
STAT
----
Pim
----
EGFR
-- MAPK
----
MEK
----
Raf
----
p38 MAPK
----
ERK
----
MNK
----
Mixed Lineage Kinase
----
JNK
----
MAP4K
-- Membrane Transporter/Ion Channel
----
BCRP
----
CFTR
----
EAAT2
----
GABA Receptor
----
HCN Channel
----
Monoamine Transporter
----
Na+/Ca2+ Exchanger
----
Na+/K+ ATPase
----
nAChR
----
Calcium Channel
----
Chloride Channel
----
CRAC Channel
----
GlyT1
----
iGluR
----
P2X Receptor
----
P-glycoprotein
----
Amino acid transporter
----
Monocarboxylate Transporter
----
Potassium Channel
----
Proton Pump
-- Metabolic Enzyme/Protease
----
PPAR
----
Proteasome
----
P450
----
Caspase
----
HSP
----
HIV Protease
----
PDE
----
MMP
----
Factor Xa
----
γ-secretase
----
Phospholipase
----
DPP4
----
FAAH
----
CETP
----
Lipoxygenase
----
HMG-CoA Reductase
----
Fatty Acid Synthase
----
NADPH-oxidase
----
FXR
----
NAMPT
----
TDO
----
Carbonic Anhydrase
----
Monoamine Oxidase
----
IDO
----
Mitochondrial Metabolism
----
Isocitrate Dehydrogenase (IDH)
----
MAGL
----
Epoxide Hydrolase
----
LXR
----
Myeloperoxidase (MPO)
----
FPTase
----
RAR/RXR
----
Acetyl-CoA Carboxylase
----
Acyltransferase
----
UGT
----
MMP
----
ATP Citrate Lyase
----
Glutaminase
----
Ketohexokinase(KHK)
----
Lipase
----
Lactate dehydrogenase
----
Glyoxalase (GLO)
----
E1/E2/E3 Enzyme
----
PANK(pantothenate kinase)
----
Phosphoglycerate Dehydrogenase (PHGDH)
-- Neuronal Signaling
----
COX
----
Histamine Receptor
----
Dopamine Receptor
----
Opioid Receptor
----
GABA Receptor
----
OX Receptor
----
Amyloid-β
----
5-HT Receptor
----
γ-secretase
----
Adrenergic Receptor
----
NMDA Receptor
----
GlyT1
----
Beta-secretase
----
Sigma Receptor
----
mAChR
----
α-Synuclein
----
Tau Protein
----
Cannabinoid Receptor
----
Transthyretin (TTR)
----
Melanocortin Receptor
----
Glucosylceramide Synthase (GCS)
----
CGRP-Receptor
----
TRP-Channel
-- NF-κB
----
NF-κB
----
HDAC
----
IKK
----
Keap1-Nrf2
-- Protein Tyrosine Kinase
----
VEGFR
----
EGFR
----
PDGFR
----
IGF-1R
----
FLT3
----
FGFR
----
c-Kit
----
Src
----
ALK
----
Ephrin receptor
----
BTK
----
Trk receptor
----
c-Met/HGFR
----
Syk (Spleen tyrosine kinase)
----
TAM Receptor
----
ULK1
----
CSF-1R
----
TYK2
----
ROS Kinase
----
Bcr-Abl
----
FAK
----
RET
----
Phosphoglycerate Kinase (PGK)
-- PI3K/Akt/mTOR
----
PI3K
----
Akt
----
GSK-3
----
S6 Kinase
----
AMPK
----
DNA-PK
----
MELK
----
PIKfyve
----
PI4K
----
PTEN
----
mTOR
----
ATM
----
PDK-1
----
ATR
----
Vps34
-- Stem Cells & Wnt
----
GSK-3
----
JAK
----
STAT
----
ROCK
----
TGF-beta/Smad
----
Wnt
----
γ-secretase
----
β-catenin
----
smo
----
Notch
-- TGF-beta/Smad
----
PKC
----
ROCK
----
TGF-beta/Smad
-- Ubiquitin
----
Proteasome
----
p97
----
Deubiquitinase
----
DUB
-- Vitamin D Related
----
VD/VDR
-- PROTAC
----
Molecular Glues
----
PROTACs
--
Antibody-drug Conjugate/ADC Related
--
Microbiology
-- Others
----
PKK
----
Others modulator
----
Estrogen Receptor/ERR
----
ChoKα
----
Newest added products
-- Nuclear Receptor
----
Androgen Receptor(AR)
Inhibitors & Agonists
Intermediates
Building Blocks
--
Aldehydes
--
Amines
--
Amino Acids
--
Anilines
--
Boronic Acids
--
Bromides
--
Carboxes
--
Catalysts
--
Chiral Compounds
--
Deuterated
--
Fluorides
--
Imidazoles
--
Indoles and Oxindoles
--
Iodos
--
Nitro Compounds
--
Oxazoles
--
Peg Linkers
--
Phenols
--
Piperidines
--
Pyridines
--
Pyrimidines
--
Quinolines
--
Sulfonamides
--
Thiazoles
--
Trifluoroborates
--
Other Azoles
--
Other Heterocycles
--
Other Building Blocks
--
On Sale
New Products
Natural Compounds
Latest Products
Avasopasem manganese (GC-4419; M-40419)
(Catalog# : 25108, Cas# :
435327-40-5
)
Avasopasem manganese, also known as GC-4419; M 40419 and SC-72325A, is amimetic of th
Iclepertin (BI-425809)
(Catalog# : 24084, Cas# :
1421936-85-7
)
Iclepertin (BI-425809) is an oral, small-molecule inhibitor of GlyT-1for the treatmen
Kartogenin ( KGN )
(Catalog# : 52215, Cas# :
4727-31-5
)
Kartogenin (KGN) is a synthetic small molecule that stimulates chondrogenic cellular
Imisopasem manganese ( M40403; GC4403 )
(Catalog# : 72602, Cas# :
218791-21-0
)
Imisopasem manganese ( M40403; GC4403 ) is a stable non-peptidyl mimetic of MnSOD tha
Apecotrep (BI 764198)
(Catalog# : 26A048, Cas# :
2311863-36-0
)
Apecotrep (BI 764198) is a potential first-in-class, oral, selective TRPC6 inhibitor.
Pantothenate kinase-IN-2
(Catalog# : 26A038, Cas# :
902614-04-4
)
Pantothenate kinase-IN-2 is a pantothenate kinase inhibitor with IC50 values of 92 nM
BH-30643
(Catalog# : 26A047, Cas# :
3062177-59-4
)
BH-30643 is a novel, orally available, non-covalent, macrocyclic, mutant selective OM
Gridegalutamide
(Catalog# : 26A044, Cas# :
2446929-86-6
)
gridegalutamide is an orally bioavailable androgen receptor (AR) degrader, with poten
BMS-986365 (Synonyms: CC-94676 )
(Catalog# : 25138, Cas# :
2446928-30-7
)
BMS-986365, also known as CC-94676, is an orally bioavailable androgen receptor (AR)
CBR-5884
(Catalog# : 24109, Cas# :
681159-27-3
)
CBR 5884 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor which was able to inhi