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PD0166285

Catalog No.: 16122710
Cas No.: 185039-89-8
Purity : 98% 
16122710 - PD0166285 | CAS 185039-89-8

Catalog number : 16122710

CAS number : 185039-89-8

Molecular Formula : C26H27Cl2N5O2 

Molecular Weight : 512.43 

Iupac Chemical Name : PD0166285 

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SynonymsN/A 
Molecular FormulaC26H27Cl2N5O2 
Molecular Weight512.43 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.PD0166285 is identified to inhibit Wee1 activity at nanomolar concentrations. The inhibitor abrogates G2/M checkpoint inducing early cell division. At the cellular level, 0.5 M PD0166285 dramatically inhibits irradiation-induced Cdc2 phosphorylation at the Tyr-15 and Thr-14 in seven of seven cancer cell lines tested. This G2 checkpoint abrogation by PD0166285 is demonstrated to kill cancer cells. PD0166285 does not inhibit Cdc2/cyclin B but inhibits Chk1 kinase at a much higher concentration (3433 nM). the treatment of cells with the inhibitor is related to microtubule stabilization and decrease in cyclin D transcription. Thus, PD0166285 may be a potentially useful anti-cancer therapy 

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