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Pleconaril

Catalog No.: 17030111
Cas No.: 153168-05-9
Purity : 98% 
17030111 - Pleconaril | CAS 153168-05-9

Catalog number : 17030111

CAS number : 153168-05-9

Molecular Formula : C18H18F3N3O3 

Molecular Weight : 381.35 

Iupac Chemical Name : 3-(3,5-dimethyl-4-(3-(3-methylisoxazol-5-yl)propoxy)phenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole 

Smile : CC=1C=C(C=C(C1OCCCC1=CC(=NO1)C)C)C1=NOC(=N1)C(F)(F)F

InChiKey : KQOXLKOJHVFTRN-UHFFFAOYSA-N

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SynonymsSR-263843; SR-63843; VP-63843; Win-63843; SR263843; SR63843; VP63843; Win63843; SR 263843; SR 63843; VP 63843; Win 63843; Pleconaril, Picovir. 
Molecular FormulaC18H18F3N3O3 
Molecular Weight381.35 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCC=1C=C(C=C(C1OCCCC1=CC(=NO1)C)C)C1=NOC(=N1)C(F)(F)F
InChiKeyKQOXLKOJHVFTRN-UHFFFAOYSA-N
InChiInChI=1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3
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Pleconaril is an antiviral drug potentially for the treatment of enterovirus infection and asthma. Pleconaril, administered either orally or intranasally, is active against viruses in the Picornaviridae family, including Enterovirus and Rhinovirus.It has shown useful activity against the dangerous strain enterovirus D68. Pleconaril binds to a hydrophobic pocket in the VP1 protein. Pleconaril has been shown in viral assembly to associate with viral particles.[9] Through noncovalent, hydrophobic interactions compounds can bind to the hydrophobic pocket. Amino acids in positions Tyr152 and Val191 are a part of the VP1 drug binding pocket. 

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