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PD-161570

Catalog No.: 17030304
Cas No.: 192705-80-9
Purity : 98% 
17030304 - PD-161570 | CAS 192705-80-9

Catalog number : 17030304

CAS number : 192705-80-9

Molecular Formula : C26H35Cl2N7O 

Molecular Weight : 532.514 

Iupac Chemical Name : PD-161570 

Smile : CCN(CC)CCCCNc1ncc2cc(c(nc2n1)NC(=O)NC(C)(C)C)c3c(cccc3Cl)Cl

InChiKey : MKVMEJKNLUWFSQ-UHFFFAOYSA-N

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SynonymsPD-161570; PD 161570; PD161570 
Molecular FormulaC26H35Cl2N7O 
Molecular Weight532.514 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCCN(CC)CCCCNc1ncc2cc(c(nc2n1)NC(=O)NC(C)(C)C)c3c(cccc3Cl)Cl
InChiKeyMKVMEJKNLUWFSQ-UHFFFAOYSA-N
InChiInChI=1S/C26H35Cl2N7O/c1-6-35(7-2)14-9-8-13-29-24-30-16-17-15-18(21-19(27)11-10-12-20(21)28)23(31-22(17)32-24)33-25(36)34-26(3,4)5/h10-12,15-16H,6-9,13-14H2,1-5H3,(H3,29,30,31,32,33,34,36)
MDLMFCD16618403
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PD-161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). PD 161570 had about 5- and 100-fold greater selectivity toward the FGF-1 receptor (IC50 = 40 nM) compared with the PDGFbeta receptor (IC50 = 262 nM) or EGF receptor (IC50 = 3.7 microM) tyrosine kinases, respectively. In addition, PD 161570 suppressed constitutive phosphorylation of the FGF-1 receptor in both human ovarian carcinoma cells (A121(p)) and Sf9 insect cells overexpressing the human FGF-1 receptor and blocked the growth of A121(p) cells in culture. The results demonstrate a novel synthetic inhibitor with nanomolar potency and specificity towards the FGF-1 receptor tyrosine kinase. 

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