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• PFI-2 (Catalog# : 52113, Cas# : 1627676-59-8)PFI-2 is a potent, selective, and cell-activelysine methyltransferase SETD7inhibitor withKi (app)andIC50of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases a
• Ponatinib (AP24534) (Catalog# : 52107, Cas# : 943319-70-8)Ponatinib (AP24534) is a novel, potent multi-target inhibitor ofAbl, PDGFR, VEGFR2, FGFR1 and Src withIC50of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively
• Palbociclib (Catalog# : 52001, Cas# : 571190-30-2)Palbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity
• Palbociclib(PD-0332991)HCl (Catalog# : 52011, Cas# : 827022-32-2)Palbociclib (PD-0332991) HCl is a highly selective inhibitor ofCDK4/6withIC50of 11 nM/16 nM respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Pha
• Palbociclib (PD0332991) Isethionate (Catalog# : 52012, Cas# : 827022-33-3)Palbociclib (PD0332991) Isethionate is a highly selective inhibitor ofCDK4/6withIC50of 11 nM/16 nM. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.
• PF-06463922 (Catalog# : 51701, Cas# : 1454846-35-5)PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and Cros oncogene 1 (Ros1), with potential antine