PF-06273340
Catalog No: 17030201
CAS Number: 1402438-74-7
Purity: 98%
PF-06273340 is a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor with an excellent LipE profile (IC50 value: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 10−6 cm s−1). PF-06273340 is well-tolerated was selected as a candidate for clinical development.
For research use only. We do not sell to patients.
Chemical Information
| Name | PF-06273340 |
|---|---|
| Iupac Chemical Name | N-(5-(2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide |
| Synonyms | PF-06273340; PF 06273340; PF06273340; PF-6273340; PF 6273340; PF6273340 |
| Molecular Formula | C23H22ClN7O3 |
| Molecular Weight | 479.925 |
| Smile | NC=1N=CC2=C(N1)N(C=C2C(=O)C=2C=C(C=NC2)NC(CC2=NC=C(C=C2)Cl)=O)C(CO)(C)C |
| InChiKey | BPIWZDNVMQQBQX-UHFFFAOYSA-N |
| InChi | InChI=1S/C23H22ClN7O3/c1-23(2,12-32)31-11-18(17-10-28-22(25)30-21(17)31)20(34)13-5-16(9-26-7-13)29-19(33)6-15-4-3-14(24)8-27-15/h3-5,7-11,32H,6,12H2,1-2H3,(H,29,33)(H2,25,28,30) |
| CAS Number | 1402438-74-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
