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PF-06273340

Catalog No.: 17030201
Cas No.: 1402438-74-7
Purity : 98% 
17030201 - PF-06273340 | CAS 1402438-74-7

Catalog number : 17030201

CAS number : 1402438-74-7

Molecular Formula : C23H22ClN7O3 

Molecular Weight : 479.925 

Iupac Chemical Name : N-(5-(2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide 

Smile : NC=1N=CC2=C(N1)N(C=C2C(=O)C=2C=C(C=NC2)NC(CC2=NC=C(C=C2)Cl)=O)C(CO)(C)C

InChiKey : BPIWZDNVMQQBQX-UHFFFAOYSA-N

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SynonymsPF-06273340; PF 06273340; PF06273340; PF-6273340; PF 6273340; PF6273340 
Molecular FormulaC23H22ClN7O3 
Molecular Weight479.925 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileNC=1N=CC2=C(N1)N(C=C2C(=O)C=2C=C(C=NC2)NC(CC2=NC=C(C=C2)Cl)=O)C(CO)(C)C
InChiKeyBPIWZDNVMQQBQX-UHFFFAOYSA-N
InChiInChI=1S/C23H22ClN7O3/c1-23(2,12-32)31-11-18(17-10-28-22(25)30-21(17)31)20(34)13-5-16(9-26-7-13)29-19(33)6-15-4-3-14(24)8-27-15/h3-5,7-11,32H,6,12H2,1-2H3,(H,29,33)(H2,25,28,30)
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PF-06273340 is a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor with an excellent LipE profile (IC50 value: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 10−6 cm s−1). PF-06273340 is well-tolerated was selected as a candidate for clinical development. 

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