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PF-5274857

Catalog No: 010423
CAS Number: 1373615-35-0
Purity: 98% 

PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the bloodCbrain barrier. 

For research use only. We do not sell to patients.

Chemical Information

NamePF-5274857
Iupac Chemical Name1-[4-[5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl]piperazin-1-yl]-3-methylsulfonylpropan-1-one 
SynonymsPF 5274857; PF5274857 
Molecular FormulaC20H25ClN4O3S 
Molecular Weight436.956 
SmileCC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C
InChiKeyBBVNTTZIOTWDSV-UHFFFAOYSA-N
InChiInChI=1S/C20H25ClN4O3S/c1-14-10-15(2)20(23-12-14)16-11-18(22-13-17(16)21)24-5-7-25(8-6-24)19(26)4-9-29(3,27)28/h10-13H,4-9H2,1-3H3
CAS Number1373615-35-0
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationSolid powder 
Purity98% 
Storage-20 ºC for 3 years 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

010423 - PF-5274857 | CAS 1373615-35-0

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