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• 2-Amino-4'-fluorobenzophenone (Catalog# : 81304, Cas# : 3800-06-4)Related API & intermediates: Cas#147526-32-7 Pitavastatin Calcium Cas# 24922-02-9 Ethyl 3-cyclopropyl-3-oxopropanoate Cas# 32249-35-7 Methyl 3-cyclopropyl-3-oxopropan
• 4-Acetoxy-3-bromobenzoic acid (Catalog# : 81012, Cas# : 72415-57-7)Coming soon!
• AC710 (Catalog# : 80702, Cas# : 1351522-04-7)AC710 is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFR/PDGFR respectively.
• 4-Amino-3-iodobenzoic acid (Catalog# : 80311, Cas# : 2122-63-6)Coming soon!
• ALPHA-BENZYL-4,6-O-BENZYLIDENE-MURAMIC ACID (Catalog# : 80302, Cas# : 19229-57-3)Coming soon
• AZD2014(Vistusertib) (Catalog# : 71804, Cas# : 1009298-59-2)1) Sponsor:AstraZeneca 2) Phase:Phase II 3) AZD2014 is a potent (IC50 2.81 nM), selective (inactive against 220 other kinases) inhibitor of mTOR kinase. It Inhibited downstream
• AZD9496 (Catalog# : 71802, Cas# : 1639042-08-2)1) Sponsor:AstraZeneca 2) Phase:Phase 1 3)AZD9496 is a novel, oral selective oestrogen receptor down-regulator (SERD),used for patients with oestrogen receptor positive (ER+)
• Alpelisib(BYL719) (Catalog# : 62504, Cas# : 1217486-61-7)NVP-BYL719 is novel and specific PI3K inhibitor.NVP-BYL719 has displayed promising results in cancer therapy and is currently under clinical trials.
• Apitolisib(GDC-0980,RG7422) (Catalog# : 62503, Cas# : 1032754-93-0)Apitolisib(GDC-0980,RG7422) is a dual PI3K/mTOR inhibitor.GDC-0980 was potent across a broad panel of cancer cell lines, with the greatest potency in breast, prostate, and lung c
• Atazanavir (Catalog# : 61005, Cas# : 198904-31-3)Atazanavir(BMS-232632) is an highly potent HIV-1 protease inhibitor.
• Abexinostat (Catalog# : 60702, Cas# : 783355-60-2)Abexinostat is a novel hydroxamate-based HDACi that showed broad spectrum anticancer activities in preclinical studies.
• Axitinib (Catalog# : 52771, Cas# : 319460-85-0)This product is no information for the time being
• AVL-292 (Catalog# : 52770, Cas# : 1202757-89-8)AVL-292 is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM; >1400-fold selectivity over the other kinases assayed.
• AT9283 (Catalog# : 52769, Cas# : 896466-04-9)AT9283 is a small molecule a multi-targeted inhibitor with IC50s of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl(T3151), JAK2 and JAK3, Aurora A and Aurora B, respectively.
• AT13387 (Catalog# : 52768, Cas# : 912999-49-6)AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity.
• Asenapine maleate (Catalog# : 52767, Cas# : 85650-56-2)Asenapine maleate(Org 5222 maleate) inhibits adrenergic receptor (1, 2A, 2B, 2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of
• AP26113 (Catalog# : 52766, Cas# : 1197958-12-5)AP26113 is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK) with IC50 of 0.62 nM.
• AM095 free acid (Catalog# : 52765, Cas# : 1228690-36-5)AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 M for recombinant human or mouse LPA1 respectively.
• Adrafinil (Catalog# : 52763, Cas# : 63547-13-7)Adrafinil (CRL-40028, Olmifon), prodrug of modafinil, is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention, Adrafinil is believed
• APY0201 (Catalog# : 52759, Cas# : 1232221-74-7)APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5
• AI-10-49 (Catalog# : 52757, Cas# : 1256094-72-0)AI-10-49 is a protein-protein interaction inhibitor that selectively binds to CBF-SMMHC and disrupts its binding to RUNX1 with a FRET IC50 of 0.26 uM.
• AEE788 (Catalog# : 52750, Cas# : 497839-62-0)AEE788(NVP-AEE 788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, P
• Alogliptin Benzoate (Catalog# : 52741, Cas# : 850649-62-6)Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
• AHAS inhibitor (Catalog# : 52739, Cas# : 219793-45-0)AHAS inhibitor is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).
• AZ20 (Catalog# : 52734, Cas# : 1233339-22-4)AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM; 8-fold selectivity over mTOR(IC50=38 nM)
• Afatinib (Catalog# : 52719, Cas# : 850140-72-6)Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fo
• AICAR (Catalog# : 52702, Cas# : 2627-69-2)AICAR (Acadesine), is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disor
• AMG-319 (Catalog# : 52026, Cas# : 1608125-21-8)AMG 319 is an investigational, highly selective, small molecule inhibitor of PI3K that blocks B cell proliferation following BCR stimulation both in vitro and in vivo, inhibits b
• AMG-925 (Catalog# : 51614, Cas# : 1401033-86-0)AMG-925 is a potent and orally bioavailable dual inhibitor of CDK4 and FLT3, including many FLT3 mutants reported to date.It inhibits the proliferation of a panel of human tumor
• ABT-737 (Catalog# : 52640, Cas# : 852808-04-9)ABT-737 is a BH3 mimetic inhibitor ofBcl-xL,Bcl-2andBcl-wwithEC50of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B o