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• Abexinostat (Catalog# : 60702, Cas# : 783355-60-2)Abexinostat is a novel hydroxamate-based HDACi that showed broad spectrum anticancer activities in preclinical studies.
• Axitinib (Catalog# : 52771, Cas# : 319460-85-0)This product is no information for the time being
• AVL-292 (Catalog# : 52770, Cas# : 1202757-89-8)AVL-292 is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM; >1400-fold selectivity over the other kinases assayed.
• AT9283 (Catalog# : 52769, Cas# : 896466-04-9)AT9283 is a small molecule a multi-targeted inhibitor with IC50s of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl(T3151), JAK2 and JAK3, Aurora A and Aurora B, respectively.
• AT13387 (Catalog# : 52768, Cas# : 912999-49-6)AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity.
• Asenapine maleate (Catalog# : 52767, Cas# : 85650-56-2)Asenapine maleate(Org 5222 maleate) inhibits adrenergic receptor (1, 2A, 2B, 2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of
• AP26113 (Catalog# : 52766, Cas# : 1197958-12-5)AP26113 is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK) with IC50 of 0.62 nM.
• AM095 free acid (Catalog# : 52765, Cas# : 1228690-36-5)AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 M for recombinant human or mouse LPA1 respectively.
• Adrafinil (Catalog# : 52763, Cas# : 63547-13-7)Adrafinil (CRL-40028, Olmifon), prodrug of modafinil, is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention, Adrafinil is believed
• APY0201 (Catalog# : 52759, Cas# : 1232221-74-7)APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5
• AI-10-49 (Catalog# : 52757, Cas# : 1256094-72-0)AI-10-49 is a protein-protein interaction inhibitor that selectively binds to CBF-SMMHC and disrupts its binding to RUNX1 with a FRET IC50 of 0.26 uM.
• AEE788 (Catalog# : 52750, Cas# : 497839-62-0)AEE788(NVP-AEE 788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, P
• Alogliptin Benzoate (Catalog# : 52741, Cas# : 850649-62-6)Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
• AHAS inhibitor (Catalog# : 52739, Cas# : 219793-45-0)AHAS inhibitor is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).
• AZ20 (Catalog# : 52734, Cas# : 1233339-22-4)AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM; 8-fold selectivity over mTOR(IC50=38 nM)
• Afatinib (Catalog# : 52719, Cas# : 850140-72-6)Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fo
• AICAR (Catalog# : 52702, Cas# : 2627-69-2)AICAR (Acadesine), is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disor
• AMG-319 (Catalog# : 52026, Cas# : 1608125-21-8)AMG 319 is an investigational, highly selective, small molecule inhibitor of PI3K that blocks B cell proliferation following BCR stimulation both in vitro and in vivo, inhibits b
• AMG-925 (Catalog# : 51614, Cas# : 1401033-86-0)AMG-925 is a potent and orally bioavailable dual inhibitor of CDK4 and FLT3, including many FLT3 mutants reported to date.It inhibits the proliferation of a panel of human tumor
• ABT-737 (Catalog# : 52640, Cas# : 852808-04-9)ABT-737 is a BH3 mimetic inhibitor ofBcl-xL,Bcl-2andBcl-wwithEC50of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B o
• AZD-7762 (Catalog# : 52638, Cas# : 860352-01-8)AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM; equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.
• AZD1080 (Catalog# : 52626, Cas# : 612487-72-6)AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor of GSK3 and GSK3 with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5
• A-674563 (Catalog# : 52617, Cas# : 552325-73-2)A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM; also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
• Alisertib(MLN8237) (Catalog# : 52587, Cas# : 1028486-01-2)Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM; has >200-fold higher selectivity for Aurora A than Aurora B.
• AMG-208 (Catalog# : 52585, Cas# : 1002304-34-8)AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.
• AZD-5438 (Catalog# : 52577, Cas# : 602306-29-6)AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM. It is less potent to CDK5/6.
• AZD1283 (Catalog# : 52573, Cas# : 919351-41-0)AZD1283 is a potent antagonist of the P2Y12 receptor with EC50 of 3.0 ug/kg/min, TI >10; with binding IC50 of 11 nM.
• Apoptosis Activator 2 (Catalog# : 52551, Cas# : 79183-19-0)Apoptosis Activator 2 is a potent apoptosis activator; increases procaspase-9 processing and subsequent caspase-3 activation.
• AGI-6780 (Catalog# : 52547, Cas# : 1432660-47-3)AGI-6780 is the first highly potent and selective small molecule inhibitor of isocitrate dehydrogenases, which binds in an allosteric manner at the dimer interface of mutant IDH2
• AP-III-a4 (Catalog# : 52538, Cas# : 1177827-73-4)ENOblock(AP-III-a4) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer c