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AZD2281(Olaparib)

Catalog No.: 92801
Cas No.: 763113-22-0
Purity : 98% by HPLC 
92801 - AZD2281(Olaparib) | CAS 763113-22-0

Catalog number : 92801

CAS number : 763113-22-0

Molecular Formula : C24H23FN4O3 

Molecular Weight : 434.46 

Iupac Chemical Name : 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine 

Smile : O=C(N1CCN(C(C2CC2)=O)CC1)C3=CC(CC4=NNC(C5=C4C=CC=C5)=O)=CC=C3F

InChiKey : FDLYAMZZIXQODN-UHFFFAOYSA-N

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SynonymsAZD-2281;AZD 2281 
Molecular FormulaC24H23FN4O3 
Molecular Weight434.46 
Appearanceoff-white solid 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
Shipping ConditionShipped under ambient temperature 
SmileO=C(N1CCN(C(C2CC2)=O)CC1)C3=CC(CC4=NNC(C5=C4C=CC=C5)=O)=CC=C3F
InChiKeyFDLYAMZZIXQODN-UHFFFAOYSA-N
InChiInChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
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Olaparib (AZD-2281, trade name Lynparza) is an FDA-approved targeted therapy for cancer, developed by KuDOS Pharmaceuticals and later by AstraZeneca. It is a PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations, which include some ovarian, breast, and prostate cancers. In December 2014, olaparib was approved for use as a single agent by the EMA and the FDA. The FDA approval is in for germline BRCA mutated (gBRCAm) advanced ovarian cancer that has received three or more prior lines of chemotherapy.

 

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