Orally administration of AS605240 significantly prevented lung inflammation and reduced collagen deposition. AS605240 also inhibited augmented expression of TNF-alpha and IL-1beta induced by bleomycin instillation. AS605240 may be a useful in treating inflammation diseases. AS605240 may represent a promising novel agent for the future therapy of pulmonary fibrosis.
For research use only. We do not sell to patients.
| Name | AS-605240 |
|---|---|
| Iupac Chemical Name | (E)-5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione |
| Synonyms | AS 605240; AS605240; AS-605240. |
| Molecular Formula | C12H7N3O2S |
| Molecular Weight | 257.27 |
| Smile | N1=CC=NC2=CC(=CC=C12)\C=C\1/C(NC(S1)=O)=O |
| InChiKey | SQWZFLMPDUSYGV-UXBLZVDNSA-N |
| InChi | InChI=1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6+ |
| CAS Number | 648450-29-7 |
| Related CAS |
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
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| Animal study | |
| Clinical study |