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Apoptozole

Catalog No.: 161014002
Cas No.: 1054543-47-3
Purity : 98% by HPLC 

Apoptosis Activator VII, Apoptozole is a cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 hours drug treatment (1 M). 

For research use only. We do not sell to patients.

Chemical Information

NameApoptozole
Molecular FormulaC33H24F6N3O3 
Molecular Weight625.6 
SmileCOc1ccc(cc1)c2c(n(c(n2)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)Cc4ccc(cc4)C(=O)N)c5ccc(cc5)OC
InChiKeyZIMMTPFXOMAJTQ-UHFFFAOYSA-N
InChiInChI=1S/C33H25F6N3O3/c1-44-26-11-7-20(8-12-26)28-29(21-9-13-27(45-2)14-10-21)42(18-19-3-5-22(6-4-19)30(40)43)31(41-28)23-15-24(32(34,35)36)17-25(16-23)33(37,38)39/h3-17H,18H2,1-2H3,(H2,40,43)
CAS Number1054543-47-3
MDLMFCD19443178
Related CAS

Ordering Information

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FormulationSolid powder 
Purity98% by HPLC 
Storage-20 ºC for 3 years 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

161014002 - Apoptozole | CAS 1054543-47-3

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