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PIM447

Catalog No.: 1710134
Cas No.: 1210608-43-7
Purity : >98%
1710134 - PIM447 | CAS 1210608-43-7

Catalog number : 1710134

CAS number : 1210608-43-7

Molecular Formula : C24H23F3N4O

Molecular Weight : 440.47021

Chemical Name : PIM447

Smile : O=C(NC1=C([C@H]2C[C@@H](N)C[C@@H](C)C2)C=CN=C1)C3=NC(C4=C(F)C=CC=C4F)=C(F)C=C3

InChiKey : VRQXRVAKPDCRCI-ZNMIVQPWSA-N

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SynonymsLGH-447; LGH 447; LGH447; PIM447; PIM-447; PIM 447.
Molecular FormulaC24H23F3N4O
Molecular Weight440.47021
Appearanceoff-white solid
Purity>98%
SolubilitySoluble in DMSO
Storage3 years -20ºCpowder
Shipping ConditionShipped under ambient temperature
SmileO=C(NC1=C([C@H]2C[C@@H](N)C[C@@H](C)C2)C=CN=C1)C3=NC(C4=C(F)C=CC=C4F)=C(F)C=C3
InChiKeyVRQXRVAKPDCRCI-ZNMIVQPWSA-N
InChiInChI=1S/C24H23F3N4O/c1-13-9-14(11-15(28)10-13)16-7-8-29-12-21(16)31-24(32)20-6-5-19(27)23(30-20)22-17(25)3-2-4-18(22)26/h2-8,12-15H,9-11,28H2,1H3,(H,31,32)/t13-,14+,15-/m0/s1
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PIM447, also known as LGH447, is a potent Moloney murine leukemia (PIM) 1, 2, and 3 kinase inhibitor. Pan proviral insertion site of Moloney murine leukemia (PIM) 1, 2, and 3 kinase inhibitors have recently begun to be tested in humans to assess whether pan PIM kinase inhibition may provide benefit to cancer patients.

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