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• SB225002 (Catalog# : 52714, Cas# : 182498-32-4)SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM; >150-fold selectivity over CXCR1 and four other 7-TMRs.
• SU9516 (Catalog# : 52579, Cas# : 377090-84-1)SU-9516 is a selective CDK2 inhibtor with IC50 of 22 nM; less potent for CDK1/CDK4(IC50=40/200 nM), no inhibition on PKC, EGFR, p38MAPK etc.
• SCH900776 (Catalog# : 52575, Cas# : 891494-63-6)SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50 = 3 nM), highly selective against Chk2 (IC50 = 1500 nM) and cyclin-dependent ki
• Selumetinib (Catalog# : 52571, Cas# : 606143-52-6)Selumetinib (AZD6244; ARRY-142886) is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38,
• Siramesine hydrochloride (Catalog# : 52549, Cas# : 224177-60-0)Siramesine(Lu 28-179) Hcl is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.
• Siramesine (Catalog# : 52548, Cas# : 147817-50-3)Siramesine(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.
• S1RA (Catalog# : 52546, Cas# : 878141-96-9)S1RA(E-52862) is a potent and selective sigma-1 receptor(1R, Ki=17 nM) antagonist, showed good selectivity against 2R (Ki > 1000 nM).
• SMI-4a (Catalog# : 52537, Cas# : 438190-29-5)SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no activity against a pane
• SKLB610 (Catalog# : 52536, Cas# : 1125780-41-7)SKLB610, a novel multi-targeted inhibitor, inhibits angiogenesis-related tyrosine kinase VEGFR2, FGFR2 and PDGFR at rate of 97%, 65% and 55%, respectively, at concentration of 10
• StemRegenin 1 (Catalog# : 52531, Cas# : 1227633-49-9)StemRegenin 1(SR1) is an antagonist of the aryl hydrocarbon receptor.SR1 is the first small molecule that promotes robust expansion/self-renewal of human CD34+ peripheral blood a
• S0859 (Catalog# : 52507, Cas# : 1019331-10-2)S0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM).
• SRPIN340 (Catalog# : 52210, Cas# : 218156-96-8)SRPIN340 is a serine/arginine-rich protein kinase (SRPK)-specific inhibitor with an IC50 value of 0.89 uM (SRPK1); no significant inhibitory activity against more than 140 other
• 5S rRNA modificator (Catalog# : 52243, Cas# : 1415238-77-5)5S rRNA modificator is a suitable electrophile for 2-hydroxyl acylation on structured RNA molecules, yielding accurate structural information comparable to that obtained with exi
• SB431542 (Catalog# : 52312, Cas# : 301836-41-9)SB431542 is a potent and selective inhibitor ofALK5withIC50of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases.
• Salirasib (Catalog# : 52106, Cas# : 162520-00-5)Salirasib(S-Farnesylthiosalicylic aci) is an S-farnesyl cysteine analog that interferes with docking of active GTP-bound ras at the cell membrane
• SNS-032(BMS-387032) (Catalog# : 52105, Cas# : 345627-80-7)SNS-032 has firstly been described as a selective inhibitor ofCDK2withIC50of 48 nM and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive toCDK7/9withI
• SNS-314 Mesylate (Catalog# : 52102, Cas# : 1057249-41-8)SNS-314 Mesylate is a potent and selective inhibitor ofAurora A,Aurora BandAurora CwithIC50of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c
• Semaxanib (SU5416) (Catalog# : 51803, Cas# : 204005-46-9)Semaxanib (SU5416) is a potent and selectiveVEGFR(Flk-1/KDR) inhibitor withIC50of 1.23 M, 20-fold more selective for VEGFR than PDGFR, lack of activity against EGFR, InsR and FGF
• SSR128129E (Catalog# : 51608, Cas# : 848318-25-2)SSR128129E is an orally-active and allostericFGFR1inhibitor withIC50of 1.9 M, while not affecting other related RTKs.
• SRT1720 (Catalog# : 52007, Cas# : 1001645-58-4)SRT1720 is a selectiveSIRT1activator withEC50of 0.16 M, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720(SRT-1720) is an experimental drug that was studied by Sirtris