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SAG(Smo-Agonist)

Catalog No.: 92802
Cas No.: 912545-86-9
Purity : 99.03% by HPLC at 254nm 

SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM). Induces pathway activation independently of Ptch proteins.

 

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Chemical Information

NameSAG(Smo-Agonist)
Iupac Chemical Name3-chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide 
Molecular FormulaC28H28ClN3OS 
Molecular Weight490.06 
SmileO=C(C1=C(Cl)C2=CC=CC=C2S1)N([C@H]3CC[C@H](NC)CC3)CC4=CC=CC(C5=CC=NC=C5)=C4
InChiKeyVFSUUTYAEQOIMW-YHBQERECSA-N
InChiInChI=1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-
CAS Number912545-86-9
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationlight yellow solid 
Purity99.03% by HPLC at 254nm 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
SolubilitySoluble in DMSO to 20 mM 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

92802 - SAG(Smo-Agonist) | CAS 912545-86-9

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