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MAPK
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Metabolic Enzyme/Protease
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+86-17702719238
sales@sun-shinechem.com
Home
Inhibitors&Agonists
Angiogenesis
Anti-infection
Apoptosis
Autophagy
Cell Cycle
Cytoskeleton
DNA Damage
Epigenetics
GPCR & G Protein
Immunology & Inflammation
JAK/STAT
MAPK
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Neuronal Signaling
NF-κB
Protein Tyrosine Kinase
PI3K/Akt/mTOR
Stem Cells & Wnt
TGF-beta/Smad
Ubiquitin
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PROTAC
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Name Index B
BML-278
(Catalog# : 20554, Cas# :
120533-76-8
)
BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective conce
BSJ-04-122
(Catalog# : 20550, Cas# :
2513289-74-0
)
brigimadlin
(Catalog# : 20533, Cas# :
2095116-40-6
)
Brigimadlin is an E3 ubiquitin-protein ligase Mdm2 inhibitor with potential as an ant
BMS-986120
(Catalog# : 20519, Cas# :
1478712-37-6
)
BMS-986120 is a potent and selective oral antagonist of protease-activated receptor-4
BMS-986141
(Catalog# : 20518, Cas# :
1478711-48-6
)
BMS-986141 is an Orally-Active Small-Molecule Antagonist of the Platelet Protease-Act
BDTX-1535
(Catalog# : 20512, Cas# :
2607829-38-7
)
BDTX-1535 is a brain-penetrant and potent MasterKey inhibitor of oncogenic mutations
Brepocitinib Tosylate
(Catalog# : 232252, Cas# :
2140301-96-6
)
Brepocitinib ( PF-06700841 ) is an orally available, selective inhibitor of non-recep
BRD4 degrader AT1
(Catalog# : 20496, Cas# :
2098836-45-2
)
BRD4 degrader AT1 is an analogue of MZ1. It shows improved selectivity for BRD4 degra
BJJF078
(Catalog# : 20492, Cas# :
2531244-56-9
)
BJJF078 is a potent inhibitor of recombinant human and mouse Transglutaminase enzyme
BRD0639
(Catalog# : 20485, Cas# :
2760881-74-9
)
BRD0639 is a potent PRMT5 inhibitor. BRD0639 engages the target in cells, disrupts PR
BI 1015550 ( Nerandomilast )
(Catalog# : 230402, Cas# :
1423719-30-5
)
BI 1015550 ( Nerandomilast )is an oral, preferential inhibitor of phosphodiesterase 4
BT44
(Catalog# : 20469, Cas# :
924759-42-2
)
BT44 is a novel RET agonist for the treatment of experimental neuropathies.
Brepocitinib ( PF-06700841 )
(Catalog# : 232251, Cas# :
1883299-62-4
)
Brepocitinib is a potential first-in-class dual, selective inhibitor of TYK2 and JAK1
BIIB068
(Catalog# : 20453, Cas# :
1798787-27-5
)
Baxdrostat
(Catalog# : 20451, Cas# :
1428652-17-8
)
Baxdrostat is an aldosterone synthase inhibitor.
BMS-986251
(Catalog# : 20445, Cas# :
2114324-48-8
)
BMS-986195
(Catalog# : 20444, Cas# :
1912445 -55-6
)
Branebrutinib
(Catalog# : 20428, Cas# :
1912445-55-6
)
Branebrutinib, also known as BMS-986195, is a potent, covalent, irreversible inhibito
Bexotegrast ( PLN-74809 )
(Catalog# : 171680, Cas# :
2376257-44-0
)
Bexotegrast (Synonyms: PLN-74809) is a small-molecule, dual selective inhibitor of α
4-Bromo-6-methylpyridine-2-carbonitrile
(Catalog# : 171653, Cas# :
886372-53-8
)
4-Bromo-6-methylpyridine-2-carbonitrile, CAS 886372-53-8
1-(4-Bromo-6- methylpyridin-2- yl)ethan-1-one
(Catalog# : 171454, Cas# :
1060810-24-3
)
1-(4-Bromo-6- methylpyridin-2- yl)ethan-1-one, CAS 1060810-24-3.
BGB-15025
(Catalog# : 171452, Cas# :
2766481-17-6
)
BGB-15025 is a potent and selective HPK1 inhibitor that is efficacious as a single ag
Benzeneacetamide, N-ethyl-4-formyl-
(Catalog# : 20419, Cas# :
2477812-42-1
)
8-[4-(2-butoxyethoxy)phenyl]-1,2,3,4-tetrahydro-1-(2-methylpropyl)-1-Benzazocine-5-carboxylic acid
(Catalog# : 20403, Cas# :
497223-19-5
)
Benzeneacetic acid, 4-[[(2,4-dimethylbenzoyl)oxy]methyl]-, methyl ester
(Catalog# : 20391, Cas# :
2097334-15-9
)
8-[4-(2-butoxyethoxy)phenyl]-1,2,3,4-tetrahydro-1-(2-methylpropyl)-1-Benzazocine-5-carboxylic acid
(Catalog# : 20386, Cas# :
497223-19-5
)
1,10-BIS[4-AZA-1-AZONIABICYCLO[2.2.2]OCTAN-1-YL]DECANE DIBROMIDE
(Catalog# : G20381, Cas# :
94630-53-2
)
6-BENZYLOXY-3,4-DIHYDRO-1H-NAPHTHALEN-2-ONE
(Catalog# : 20372, Cas# :
885280-42-2
)
BIBF0775
(Catalog# : L20357, Cas# :
334951-90-5
)
BIBF0775 is an inhibitor of the transforming growth factor β receptor I (TGFβRI). X
Blarcamesine HCl
(Catalog# : 6111905, Cas# :
195615-84-0
)
Anavex2-73 is a muscarinic/σ1 ligand. ANAVEX2-73 (0.01-3.0 mg/kg i.p.) alleviated th
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Products Catalog
Signaling Pathway
-- Angiogenesis
----
VEGFR
----
JAK
----
EGFR
----
PDGFR
----
FLT3
----
FGFR
----
Src
----
ALK
----
Syk
----
HIF
-- Anti-infection
----
CMV
----
Filovirus
----
HBV
----
HCV
----
HIV
----
HSV
----
Influenza Virus
----
RSV
----
SARS-CoV
----
Antibacterial
----
Antifungal
----
Parasite
-- Apoptosis
----
PD-1
----
PD-L1
----
Bcl-2
----
Caspase
----
TNF-alpha
----
Survivin
----
IAP
----
PERK
----
p53
----
Mdm2
----
E1/E2/E3 Enzyme
-- Autophagy
----
LRRK2
----
CXCR
----
Autophagy
-- Cell Cycle
----
CDK
----
PD-1
----
PD-L1
----
Chk
----
ROCK
----
PLK
----
APC
----
Wee1
----
DYRK
----
c-Myc
----
Aurora Kinase
----
ROCK inhibitor
----
Eukaryotic Initiation Factor (eIF)
----
NEKs
-- Cytoskeleton
----
HSP
----
Kinesin
----
Integrin
----
Dynamin
----
Wnt
----
β-catenin
----
Gap Junction Protein
-- DNA Damage
----
PARP
----
DNA/RNA Synthesis
----
Sirtuin
----
Topoisomerase
----
DNA-PK
----
Telomerase
----
RAD51
----
HDAC
----
ATM
----
DNA alkylator
----
Mps1
-- Epigenetics
----
PARP
----
JAK
----
Pim
----
PKC
----
PKD
----
Sirtuin
----
Histone Demethylase
----
Histone Acetyltransferase
----
HDAC
----
HIF-PH
----
Aurora Kinase
----
Histone Methyltransferase
----
METTL3
----
Epigenetic Reader Domain
----
Methionine Adenosyltransferase (MAT)
-- GPCR & G Protein
----
Histamine Receptor
----
Dopamine Receptor
----
Opioid Receptor
----
Endothelin Receptor
----
SGLT
----
OX Receptor
----
CaSR
----
CXCR
----
Vasopressin Receptor
----
Glucagon Receptor
----
Prostaglandin Receptor
----
5-HT Receptor
----
Adrenergic Receptor
----
Cannabinoid Receptor
----
Sphingosine 1 Phosphate Receptor
----
PKA
----
Adenosine Receptor
----
GnRH
----
LPL Receptor
----
Ras
----
Cholecystokinin Receptor
----
Melanocortin Receptor
----
RXFP Receptor
----
Bradykinin Receptor
----
GLP Receptor
----
SSTR
-- Immunology & Inflammation
----
PD-1
----
PD-L1
----
COX
----
CCR
----
Histamine Receptor
----
TLR
----
CXCR
----
MALT
----
TDO
----
NOS
----
IDO
----
Thrombopoietin Receptor(TPO)
----
NLR inhibitor
----
Interleukin Related
----
CD73
----
Complement System
----
Aryl Hydrocarbon Receptor
----
Kallikrein
----
IRAK
----
Reactive Oxygen Species(ROS)
----
SOD
-- JAK/STAT
----
JAK
----
STAT
----
Pim
----
EGFR
-- MAPK
----
MEK
----
Raf
----
p38 MAPK
----
ERK
----
MNK
----
Mixed Lineage Kinase
----
JNK
----
MAP4K
-- Membrane Transporter/Ion Channel
----
BCRP
----
CFTR
----
EAAT2
----
GABA Receptor
----
HCN Channel
----
Monoamine Transporter
----
Na+/Ca2+ Exchanger
----
Na+/K+ ATPase
----
nAChR
----
Calcium Channel
----
Chloride Channel
----
CRAC Channel
----
GlyT1
----
iGluR
----
P2X Receptor
----
P-glycoprotein
----
Amino acid transporter
----
Monocarboxylate Transporter
----
Potassium Channel
----
Proton Pump
-- Metabolic Enzyme/Protease
----
PPAR
----
Proteasome
----
P450
----
Caspase
----
HSP
----
HIV Protease
----
PDE
----
MMP
----
Factor Xa
----
γ-secretase
----
Phospholipase
----
DPP4
----
FAAH
----
CETP
----
Lipoxygenase
----
HMG-CoA Reductase
----
Fatty Acid Synthase
----
NADPH-oxidase
----
FXR
----
NAMPT
----
TDO
----
Carbonic Anhydrase
----
Monoamine Oxidase
----
IDO
----
Mitochondrial Metabolism
----
Isocitrate Dehydrogenase (IDH)
----
MAGL
----
Epoxide Hydrolase
----
LXR
----
Myeloperoxidase (MPO)
----
FPTase
----
RAR/RXR
----
Acetyl-CoA Carboxylase
----
Acyltransferase
----
UGT
----
MMP
----
ATP Citrate Lyase
----
Glutaminase
----
Ketohexokinase(KHK)
----
Lipase
----
Lactate dehydrogenase
----
Glyoxalase (GLO)
----
E1/E2/E3 Enzyme
----
PANK(pantothenate kinase)
----
Phosphoglycerate Dehydrogenase (PHGDH)
----
Hemoglobin
-- Neuronal Signaling
----
COX
----
Histamine Receptor
----
Dopamine Receptor
----
Opioid Receptor
----
GABA Receptor
----
OX Receptor
----
Amyloid-β
----
5-HT Receptor
----
γ-secretase
----
Adrenergic Receptor
----
NMDA Receptor
----
GlyT1
----
Beta-secretase
----
Sigma Receptor
----
mAChR
----
α-Synuclein
----
Tau Protein
----
Cannabinoid Receptor
----
Transthyretin (TTR)
----
Melanocortin Receptor
----
Glucosylceramide Synthase (GCS)
----
CGRP-Receptor
----
TRP-Channel
-- NF-κB
----
NF-κB
----
HDAC
----
IKK
----
Keap1-Nrf2
-- Protein Tyrosine Kinase
----
VEGFR
----
EGFR
----
PDGFR
----
IGF-1R
----
FLT3
----
FGFR
----
c-Kit
----
Src
----
ALK
----
Ephrin receptor
----
BTK
----
Trk receptor
----
c-Met/HGFR
----
Syk (Spleen tyrosine kinase)
----
TAM Receptor
----
ULK1
----
CSF-1R
----
TYK2
----
ROS Kinase
----
Bcr-Abl
----
FAK
----
RET
----
Phosphoglycerate Kinase (PGK)
-- PI3K/Akt/mTOR
----
PI3K
----
Akt
----
GSK-3
----
S6 Kinase
----
AMPK
----
DNA-PK
----
MELK
----
PIKfyve
----
PI4K
----
PTEN
----
mTOR
----
ATM
----
PDK-1
----
ATR
----
Vps34
-- Stem Cells & Wnt
----
GSK-3
----
JAK
----
STAT
----
ROCK
----
TGF-beta/Smad
----
Wnt
----
γ-secretase
----
β-catenin
----
smo
----
Notch
-- TGF-beta/Smad
----
PKC
----
ROCK
----
TGF-beta/Smad
-- Ubiquitin
----
Proteasome
----
p97
----
Deubiquitinase
----
DUB
-- Vitamin D Related
----
VD/VDR
-- PROTAC
----
Molecular Glues
----
PROTACs
--
Antibody-drug Conjugate/ADC Related
--
Microbiology
-- Others
----
PKK
----
Others modulator
----
Estrogen Receptor/ERR
----
ChoKα
----
Newest added products
-- Nuclear Receptor
----
Androgen Receptor(AR)
Inhibitors & Agonists
Intermediates
Building Blocks
--
Aldehydes
--
Amines
--
Amino Acids
--
Anilines
--
Boronic Acids
--
Bromides
--
Carboxes
--
Catalysts
--
Chiral Compounds
--
Deuterated
--
Fluorides
--
Imidazoles
--
Indoles and Oxindoles
--
Iodos
--
Nitro Compounds
--
Oxazoles
--
Peg Linkers
--
Phenols
--
Piperidines
--
Pyridines
--
Pyrimidines
--
Quinolines
--
Sulfonamides
--
Thiazoles
--
Trifluoroborates
--
Other Azoles
--
Other Heterocycles
--
Other Building Blocks
--
On Sale
New Products
Natural Compounds
Latest Products
MRX-2843
(Catalog# : 26A087, Cas# :
1429882-07-4
)
MRX-2843 is an orally bioavailable inhibitor of two receptor tyrosine kinases (RTKs),
GDC-0134
(Catalog# : 20432, Cas# :
1637394-01-4
)
GDC-0134 is a MAP3K12 (DLK) Inhibitor.
BI-847325
(Catalog# : 25046, Cas# :
2128698-24-6
)
BI-847325 is a novel, ATP-competitive, orally available inhibitor of Aurora kinases a
GDD-261
(Catalog# : 26A084, Cas# :
3137699-54-5
)
GDD-261 is an orally active, allosteric inhibitor of phosphoglycerate dehydrogenase (
Atebimetinib
(Catalog# : 25148, Cas# :
2669009-92-9
)
Atebimetinib (IMM-1-104) is an oral, small-molecule allosteric inhibitor of the MEK1
BH-30643
(Catalog# : 26A047, Cas# :
3062177-59-4
)
BH-30643 is a novel, orally available, non-covalent, macrocyclic, mutant selective OM
ERAS-801 ( JGK-068S )
(Catalog# : 20635, Cas# :
2490431-16-6
)
ERAS-801 ( JGK-068S ) is a potent EGFR inhibitor.
Aderamastat ( Synonyms: FP-025 )
(Catalog# : 26A086, Cas# :
877176-23-3
)
Aderamastat (FP-025) is an oral, selective, non-hydroxamate-based, non-competitive in
5-Formyl-4-methyl-1H-indole-2-carbonitrile
(Catalog# : 25095, Cas# :
1857296-22-0
)
MAT2A inhibitor-[Compound 1]
(Catalog# : 26A083, Cas# :
2923986-48-3
)
Compound 1 is a new MAT2A inhibitor.