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Bexotegrast ( PLN-74809 )

Catalog No: 171680
CAS Number: 2376257-44-0
Purity: ≧98.0%

Bexotegrast  (Synonyms: PLN-74809) is a small-molecule, dual selective inhibitor of αVβ1 / αVβ6 for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). These integrins cause upstream activation of TGF-β1 in actively fibrotic tissue. Inhibition of these integrins will block TGF-β1 activation, thereby preventing the growth of fibrotic tissue within the lung and bile ducts.

For research use only. We do not sell to patients.

Chemical Information

NameBexotegrast ( PLN-74809 )
Iupac Chemical Name(S)-4-((2-methoxyethyl)(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl)amino)-2-(quinazolin-4-ylamino)butanoic acid
SynonymsPLN-74809 ; PLN 74809 ; PLN74809 ; Bexotegrast ;
Molecular FormulaC27H36N6O3
Molecular Weight492.61
CAS Number2376257-44-0
Related CAS2376257-44-0

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
Request Bulk Quote Download MSDS Tel : +86-27-65522453   Email : sales@sun-shinechem.com
FormulationOff-white to light-yellow solid
StorageDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
SolubilitySoluble in DMSO
HandlingRefer to MSDS
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code2934200090
Coming soon.
Targets αVβ1 / αVβ6 inhibitor
Cell study
Animal study
Clinical study
Not available

Chemical Structure

171680 - Bexotegrast  ( PLN-74809 ) | CAS 2376257-44-0

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