Bexotegrast ( PLN-74809 )
Catalog No: 171680
CAS Number: 2376257-44-0
Purity: ≧98.0%
Bexotegrast (Synonyms: PLN-74809) is a small-molecule, dual selective inhibitor of αVβ1 / αVβ6 for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). These integrins cause upstream activation of TGF-β1 in actively fibrotic tissue. Inhibition of these integrins will block TGF-β1 activation, thereby preventing the growth of fibrotic tissue within the lung and bile ducts.
For research use only. We do not sell to patients.
Chemical Information
| Name | Bexotegrast ( PLN-74809 ) |
|---|---|
| Iupac Chemical Name | (S)-4-((2-methoxyethyl)(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl)amino)-2-(quinazolin-4-ylamino)butanoic acid |
| Synonyms | PLN-74809 ; PLN 74809 ; PLN74809 ; Bexotegrast ; |
| Molecular Formula | C27H36N6O3 |
| Molecular Weight | 492.61 |
| Smile | O=C(O)[C@@H](NC1=C2C=CC=CC2=NC=N1)CCN(CCOC)CCCCC3=NC4=C(CCCN4)C=C3 |
| InChiKey | CWOFQJBATWQSHL-DEOSSOPVSA-N |
| InChi | InChI=1S/C27H36N6O3/c1-36-18-17-33(15-5-4-8-21-12-11-20-7-6-14-28-25(20)31-21)16-13-24(27(34)35)32-26-22-9-2-3-10-23(22)29-19-30-26/h2-3,9-12,19,24H,4-8,13-18H2,1H3,(H,28,31)(H,34,35)(H,29,30,32)/t24-/m0/s1 |
| CAS Number | 2376257-44-0 |
| Related CAS | 2376257-44-0 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white to light-yellow solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | αVβ1 / αVβ6 inhibitor |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
