BML-278
Catalog No: 20554
CAS Number: 120533-76-8
Purity: 98% Min.
BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 µM.
For research use only. We do not sell to patients.
Chemical Information
| Name | BML-278 |
|---|---|
| Iupac Chemical Name | diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate |
| Synonyms | BML-278; BML 278; BML278; diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate; Diethyl 1-benzyl-4-phenyl-4H-pyridine-3,5-dicarboxylate |
| Molecular Formula | C24H25NO4 |
| Molecular Weight | 391.46 |
| Smile | O=C(OCC)C1=CN(CC2=CC=CC=C2)C=C(C(OCC)=O)C1C3=CC=CC=C3 |
| InChiKey | JOHFECBOWRGWJZ-UHFFFAOYSA-N |
| InChi | InChI=1S/C24H25NO4/c1-3-28-23(26)20-16-25(15-18-11-7-5-8-12-18)17-21(24(27)29-4-2)22(20)19-13-9-6-10-14-19/h5-14,16-17,22H,3-4,15H2,1-2H3 |
| CAS Number | 120533-76-8 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Adamkova K, Yi YJ, Petr J, Zalmanova T, Hoskova K, Jelinkova P, Moravec J, Kralickova M, Sutovsky M, Sutovsky P, Nevoral J. SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development. J Anim Sci Biotechnol. 2017 Nov 1;8:83. doi: 10.1186/s40104-017-0214-0. PMID: 29118980; PMCID: PMC5664433.
Chemical Structure
