GDC-0134
Catalog No: 20432
CAS Number: 1637394-01-4
Purity: ≧98.0%
GDC-0134 is a MAP3K12 (DLK) Inhibitor.
For research use only. We do not sell to patients.
Chemical Information
| Name | GDC-0134 |
|---|---|
| Iupac Chemical Name | 3-(Difluoromethoxy)-5-[2-(3,3-difluoropyrrolidin-1-yl)-6-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrimidin-4-yl]pyridin-2-amine |
| Synonyms | GDC-0134; GDC0134; GDC 0134; RG-6000; RG 6000; RG6000 |
| Molecular Formula | C19H20F4N6O2 |
| Molecular Weight | 440.39 |
| Smile | NC1=NC=C(C2=NC(N5CC(F)(F)CC5)=NC(N3[C@]4([H])CO[C@](C4)([H])C3)=C2)C=C1OC(F)F |
| InChiKey | SKMKJBYBPYBDMN-RYUDHWBXSA-N |
| InChi | InChI=1S/C19H20F4N6O2/c20-17(21)31-14-3-10(6-25-16(14)24)13-5-15(29-7-12-4-11(29)8-30-12)27-18(26-13)28-2-1-19(22,23)9-28/h3,5-6,11-12,17H,1-2,4,7-9H2,(H2,24,25)/t11-,12-/m0/s1 |
| CAS Number | 1637394-01-4 |
| Related CAS | 1637394-01-4 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study | GDC-0134 is a MAP3K12 (DLK) Inhibitor which had been in early clinical trials at Genentech for the treatment of amyotrophic lateral sclerosis. However, the company discontinued the development of the product. |
Not available
Chemical Structure
-5-[2-(3,3-difluoro-1-pyrrolidinyl)-6-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-4-pyrimidinyl]-_1637394-01-4.png)