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VX-809(Lumacaftor)

Catalog No.: 92219
Cas No.: 936727-05-8
Purity : 98% 
92219 - VX-809(Lumacaftor) | CAS 936727-05-8

Catalog number : 92219

CAS number : 936727-05-8

分子式 : C24H18F2N2O5 

分子量 : 452.41 

Iupac 化学名称 : 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid 

Smile : O=C(O)C1=CC=CC(C2=NC(NC(C3(C4=CC=C(OC(F)(F)O5)C5=C4)CC3)=O)=CC=C2C)=C1

InChiKey : UFSKUSARDNFIRC-UHFFFAOYSA-N

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同义词VX809; VX 809 
英文同义词VX809; VX 809 
分子式C24H18F2N2O5 
分子量452.41 
外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileO=C(O)C1=CC=CC(C2=NC(NC(C3(C4=CC=C(OC(F)(F)O5)C5=C4)CC3)=O)=CC=C2C)=C1
InChiKeyUFSKUSARDNFIRC-UHFFFAOYSA-N
InChiInChI=1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31)
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From Wikipedia, the free encyclopedia

Lumacaftor (USAN, codenamed VX-809) is an experimental drug for the treatment of cystic fibrosis being developed by Vertex Pharmaceuticals. The drug is designed to be effective in patients that have the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR), the defective protein that causes the disease. F508del, meaning that the amino acid phenylalanine in position 508 is missing, is found in about 60% of cystic fibrosis patients in Europe, and in about 90% of persons with some mutation in the CFTR gene.

Lumacaftor acts on F508 CFTR during protein folding and suppresses misfolding.

Results from a Phase II clinical trial indicate that patients with the most common form of genetic mutation causing cystic fibrosishomozygous F508delhad a mean increase of 7.4% in lung function (FEV1) on a combination of lumacaftor and ivacaftor.However these results did not show a significant improvement in lung function.

 

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