MRTX1719
编号: 262401
Cas号: 2630904-45-7
纯度: ≧96.0%
MRTX1719 is a potent and selective binder to the PRMT5•MTA complex and selectively inhibits PRMT5 activity in MTAP-deleted cells compared to MTAP-wild-type cells. Daily oral administration of MRTX1719 to tumor xenograft-bearing mice demonstrated dose-dependent inhibition of PRMT5-dependent symmetric dimethylarginine protein modification in MTAP-deleted tumors that correlated with antitumor activity.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | MRTX1719 |
|---|---|
| Iupac 化学名称 | 2-(4-(4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile |
| 同义词 | MRTX1719 ; MRTX 1719 ; MRTX-1719 ; |
| 英文同义词 | MRTX1719 ; MRTX 1719 ; MRTX-1719 ; |
| 分子式 | C23H18ClFN6O2 |
| 分子量 | 464.89 |
| Smile | N#CC1=[C@@]([C@@]2=C(C3=CC4=C(C(NN=C4CN)=O)C=C3)C=NN2C)C(F)=C(Cl)C=C1OC5CC5 |
| InChiKey | BZKIOORWZAXIBA-UHFFFAOYSA-N |
| InChi | InChI=1S/C23H18ClFN6O2/c1-31-22(20-15(8-26)19(33-12-3-4-12)7-17(24)21(20)25)16(10-28-31)11-2-5-13-14(6-11)18(9-27)29-30-23(13)32/h2,5-7,10,12H,3-4,9,27H2,1H3,(H,30,32) |
| Cas号 | 2630904-45-7 |
| 相关CAS号 | 2630904-45-7 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
|---|---|---|---|---|
| 大货 | 询价 | 询价 | 询价 |
