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AZD2014(Vistusertib)

Catalog No.: 71804
Cas No.: 1009298-59-2
Purity : 98% by HPLC 
71804 - AZD2014(Vistusertib) | CAS 1009298-59-2

Catalog number : 71804

CAS number : 1009298-59-2

分子式 : C25H30N6O3 

分子量 : 462.5 

Iupac 化学名称 : 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide 

Smile : O=C(NC)C1=CC=CC(C2=CC=C3C(N4[C@@H](C)COCC4)=NC(N5[C@@H](C)COCC5)=NC3=N2)=C1

InChiKey : JUSFANSTBFGBAF-IRXDYDNUSA-N

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同义词AZD 2014;AZD-2014;AZD2014;Vistusertib
英文同义词AZD 2014;AZD-2014;AZD2014;Vistusertib
分子式C25H30N6O3 
分子量462.5 
外观crystalline solid 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileO=C(NC)C1=CC=CC(C2=CC=C3C(N4[C@@H](C)COCC4)=NC(N5[C@@H](C)COCC5)=NC3=N2)=C1
InChiKeyJUSFANSTBFGBAF-IRXDYDNUSA-N
InChiInChI=1S/C25H30N6O3/c1-16-14-33-11-9-30(16)23-20-7-8-21(18-5-4-6-19(13-18)24(32)26-3)27-22(20)28-25(29-23)31-10-12-34-15-17(31)2/h4-8,13,16-17H,9-12,14-15H2,1-3H3,(H,26,32)/t16-,17-/m0/s1
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1) Sponsor:AstraZeneca
2) Phase: Phase II
3) AZD2014

is a potent (IC50 2.81 nM), selective (inactive against 220 other kinases) inhibitor of mTOR kinase. It Inhibited downstream targets of both mTORC1 (pS6 and p4EBP1) and mTORC2 (pAKT s473) in several in vitro models in a dose- and time-dependent manner.















































































 

 

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