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AZD-8835

Catalog No.: 102703
Cas No.: 1620576-64-8
Purity : 98% by HPLC at 215nm 
102703 - AZD-8835 | CAS 1620576-64-8

Catalog number : 102703

CAS number : 1620576-64-8

分子式 : C22H31N9O3 

分子量 : 469.55 

Iupac 化学名称 : 1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one 

Smile : O=C(N1CCC(C2=NN(CC)C(C3=NC(C4=NN=C(C(C)(C)C)O4)=C(N)N=C3)=N2)CC1)CCO

InChiKey : ZGRDYKFVDCFJCZ-UHFFFAOYSA-N

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同义词AZD 8835;AZD8835 
英文同义词AZD 8835;AZD8835 
分子式C22H31N9O3 
分子量469.55 
外观off-white to light yellow solid 
纯度98% by HPLC at 215nm 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileO=C(N1CCC(C2=NN(CC)C(C3=NC(C4=NN=C(C(C)(C)C)O4)=C(N)N=C3)=N2)CC1)CCO
InChiKeyZGRDYKFVDCFJCZ-UHFFFAOYSA-N
InChiInChI=1S/C22H31N9O3/c1-5-31-19(26-18(29-31)13-6-9-30(10-7-13)15(33)8-11-32)14-12-24-17(23)16(25-14)20-27-28-21(34-20)22(2,3)4/h12-13,32H,5-11H2,1-4H3,(H2,23,24)
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AZD8835 is a selective, oral inhibitor of PI3K isoforms  and  with the following activity in enzymatic assays: PI3K  C IC50 = 6nM (equipotent vs wt and E545K / H1047R mutants); PI3K  C IC50 = 6nM; PI3K  C IC50 = 90nM; PI3K  C IC50 = 431nM. Inhibition of signalling  in cells (pAKT endpoint): PI3K  C IC50= 57nM; PI3K  C IC50= 49nM; PI3K  C IC50= 3.6M; PI3K -  IC50= 532nM 

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