b-AP15 is a specific inhibitor of the deubiquitinating enzymes Uch37 and Usp14 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. Treating cells with b-AP15 causes the accumulation of polyubiquitinated proteins, inhibition of proteasomal degradation, upregulation of apoptotic markers and cell death.
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化学信息
| 名称 | b-AP15 |
| Iupac 化学名称 | (3E,5E)-1-acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one |
| 同义词 | NSC687852; NSC 687852; NSC-687852 |
| 英文同义词 | NSC687852; NSC 687852; NSC-687852 |
| 分子式 | C22H17N3O6 |
| 分子量 | 419.39 |
| Smile | C(C=C)(=O)N1C\C(\C(/C(/C1)=C/C1=CC=C(C=C1)[N+](=O)[O-])=O)=C/C1=CC=C(C=C1)[N+](=O)[O-] |
| InChiKey | GFARQYQBWJLZMW-JYFOCSDGSA-N |
| InChi | InChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+ |
| Cas号 | 1009817-63-3 |
| 相关CAS号 | |
| 外观性状 | Yellow solid powder |
| 纯度 | 97% |
| 存储 | -20 ºC for 3 years |
| 可溶性 | Soluble in DMSO |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature |
| 海关编码 | |
| Targets | |
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study | |