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b-AP15

Catalog No.: 73106
Cas No.: 1009817-63-3
Purity : 97% 
73106 - b-AP15 | CAS 1009817-63-3

Catalog number : 73106

CAS number : 1009817-63-3

分子式 : C22H17N3O6 

分子量 : 419.39 

Iupac 化学名称 : (3E,5E)-1-acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one 

Smile : C(C=C)(=O)N1C\C(\C(/C(/C1)=C/C1=CC=C(C=C1)[N+](=O)[O-])=O)=C/C1=CC=C(C=C1)[N+](=O)[O-]

InChiKey : GFARQYQBWJLZMW-JYFOCSDGSA-N

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同义词NSC687852; NSC 687852; NSC-687852 
英文同义词NSC687852; NSC 687852; NSC-687852 
分子式C22H17N3O6 
分子量419.39 
外观Yellow solid powder 
纯度97% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileC(C=C)(=O)N1C\C(\C(/C(/C1)=C/C1=CC=C(C=C1)[N+](=O)[O-])=O)=C/C1=CC=C(C=C1)[N+](=O)[O-]
InChiKeyGFARQYQBWJLZMW-JYFOCSDGSA-N
InChiInChI=1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2/b17-11+,18-12+
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b-AP15 is a specific inhibitor of the deubiquitinating enzymes Uch37 and Usp14 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. Treating cells with b-AP15 causes the accumulation of polyubiquitinated proteins, inhibition of proteasomal degradation, upregulation of apoptotic markers and cell death. 

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