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ZLN024 hydrochloride

Catalog No.: 611814
Cas No.:
Purity : 98% 
611814 - ZLN024 hydrochloride

Catalog number : 611814

CAS number :

分子式 : C13H14BrClN2OS 

分子量 : 361.69 

Iupac 化学名称 : ZLN024 hydrochloride 

Smile : C[Si](C)(C)CSCCl

InChiKey : IKWIERSJEROYFH-UHFFFAOYSA-N

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同义词ZLN-024 hydrochloride 
英文同义词ZLN-024 hydrochloride 
分子式C13H14BrClN2OS 
分子量361.69 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
SmileC[Si](C)(C)CSCCl
InChiKeyIKWIERSJEROYFH-UHFFFAOYSA-N
InChiInChI=1S/C5H13ClSSi/c1-8(2,3)5-7-4-6/h4-5H2,1-3H3
MDLMFCD17013410
Coming soon.

ZLN024 Hcl is a novel AMPK allosteric activator; activated 111 and 211 by around 2C2.5 fold with an EC50 of about 1C2 uM. 


ZLN024 activated AMPK in L6 myotubes and stimulated glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio. ZLN024 also activated AMPK in primary hepatocytes, decreased fatty acid synthesis and glucose output. Treatment of db/db mice with 15 mg/kg/day ZLN024 improved glucose tolerance; liver tissue weight, triacylglycerol and the total cholesterol content were decreased. The hepatic transcriptional level of G6Pase, FAS and mtGPAT were reduced.


 

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