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ZL006

Catalog No.: 16122851
Cas No.: 1181226-02-7
Purity : 98% 

ZL006 is a PSD95-nNOS protein-protein interaction inhibitor. ZL006 (EC50: 12.88 M) directly inhibited binding of purified PSD95 and nNOS proteins in AlphaScreen without altering binding of PSD95 to ErbB4. ZL006 preferentially suppressed phase 2A pain behavior in the formalin test and suppressed allodynia induced by intraplantar complete Freund's adjuvant administration. Disrupting PSD95-nNOS protein-protein interactions is effective in attenuating pathological pain without producing unwanted side effects (i.e. motor ataxia) associated with NMDAR antagonists. 

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Chemical Information

名称ZL006
Iupac 化学名称ZL006 
同义词ZL006; ZL-006; ZL 006 
英文同义词ZL006; ZL-006; ZL 006 
分子式C14H11Cl2NO4 
分子量328.145 
Smilec1cc(c(cc1NCc2cc(cc(c2O)Cl)Cl)O)C(=O)O
InChiKeyRTEYSQSXRFVKTJ-UHFFFAOYSA-N
InChiInChI=1S/C14H11Cl2NO4/c15-8-3-7(13(19)11(16)4-8)6-17-9-1-2-10(14(20)21)12(18)5-9/h1-5,17-19H,6H2,(H,20,21)
Cas号1181226-02-7
MDLMFCD20527326
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Ordering Information

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Formulationcrystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
Handling
运输条件Shipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

16122851 - ZL006 | CAS 1181226-02-7

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