YM-90709
编号: 16122849
Cas号: 163769-88-8
纯度: 98%
YM-90709 is an interleukin-5 receptor antagonist. YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC50 values of 1.0 and 0.57 microM, respectively. In functional assays, YM-90709 inhibited IL-5-prolonged eosinophil survival with an IC50 value of 0.45 microM and did not affect the GM-CSF-prolonged eosinophil survival. Furthermore, YM-90709 inhibited the IL-5-induced but not GM-CSF-induced tyrosine phosphorylation of Janus kinase 2 (JAK2) in eosinophilic HL-60 clone 15 cells.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | YM-90709 |
|---|---|
| Iupac 化学名称 | YM-90709 |
| 同义词 | YM-90709; YM 90709; YM90709 |
| 英文同义词 | YM-90709; YM 90709; YM90709 |
| 分子式 | C22H21N3O2 |
| 分子量 | 359.429 |
| Smile | CC1(Cc2cc(c(cc2-c3n1c4c(c3)nc5ccccc5n4)OC)OC)C |
| InChiKey | HIXSPVQXXDULHS-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3 |
| Cas号 | 163769-88-8 |
| MDL | MFCD00354370 |
| 相关CAS号 |
订购信息
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