Welcome to Sun-shine chemical
+86-27-65522453 sales@sun-shinechem.com

YM-155 hydrochloride

Catalog No.: 6111414
Cas No.: 355406-09-6
Purity : 98% 

YM155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM.


YM155 completely inhibits the tumor growth of PC-3 s.c. xenografted prostate tumors at doses of 3 and 10 mg/kg, without body weight loss and blood cell count decrease. Pharmacokinetic analysis shows that YM155 is highly distributed to tumor tissue. Moreover, YM155 shows 80% TGI at a dose of 5 mg/kg in PC-3 orthotopic xenografts. The combination therapy with YM155 and -radiation shows great antitumor activity against H460 or Calu6 xenografts in nude mice.


 

For research use only. We do not sell to patients.

Chemical Information

名称YM-155 hydrochloride
Iupac 化学名称YM-155 hydrochloride 
同义词YM155 hydrochloride; YM 155 hydrochloride 
英文同义词YM155 hydrochloride; YM 155 hydrochloride 
分子式C20H19ClN4O3 
分子量398.84 
SmileCc1n(c2c([n+]1Cc3cnccn3)C(=O)c4ccccc4C2=O)CCOC.[Cl-]
InChiKeyNUZWGSASIPTGSA-UHFFFAOYSA-M
InChiInChI=1S/C20H19N4O3.ClH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1
Cas号355406-09-6
MDLMFCD18207200
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS 电话 : +86-27-65522453   Email : sales@sun-shinechem.com
Formulationcrystalline solid 
纯度98% 
存储3 years -20ºCpowder 
可溶性Soluble in DMSO 
Handling
运输条件Shipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

化学结构

6111414 - YM-155 hydrochloride | CAS 355406-09-6

Quick inquiry

Change