YM-155 hydrochloride
编号: 6111414
Cas号: 355406-09-6
纯度: 98%
YM155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM.
YM155 completely inhibits the tumor growth of PC-3 s.c. xenografted prostate tumors at doses of 3 and 10 mg/kg, without body weight loss and blood cell count decrease. Pharmacokinetic analysis shows that YM155 is highly distributed to tumor tissue. Moreover, YM155 shows 80% TGI at a dose of 5 mg/kg in PC-3 orthotopic xenografts. The combination therapy with YM155 and -radiation shows great antitumor activity against H460 or Calu6 xenografts in nude mice.
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | YM-155 hydrochloride |
|---|---|
| Iupac 化学名称 | YM-155 hydrochloride |
| 同义词 | YM155 hydrochloride; YM 155 hydrochloride |
| 英文同义词 | YM155 hydrochloride; YM 155 hydrochloride |
| 分子式 | C20H19ClN4O3 |
| 分子量 | 398.84 |
| Smile | Cc1n(c2c([n+]1Cc3cnccn3)C(=O)c4ccccc4C2=O)CCOC.[Cl-] |
| InChiKey | NUZWGSASIPTGSA-UHFFFAOYSA-M |
| InChi | InChI=1S/C20H19N4O3.ClH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1 |
| Cas号 | 355406-09-6 |
| MDL | MFCD18207200 |
| 相关CAS号 |
订购信息
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