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YLF-466D

Catalog No.: 611813
Cas No.: 1273323-67-3
Purity : 98% 
611813 - YLF-466D | CAS 1273323-67-3

Catalog number : 611813

CAS number : 1273323-67-3

分子式 : C29H20ClNO3 

分子量 : 465.93 

Iupac 化学名称 : YLF-466D 

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同义词(C24; YLF 466D; YLF466D 
英文同义词(C24; YLF 466D; YLF466D 
分子式C29H20ClNO3 
分子量465.93 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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YLF-466D is an allosteric AMPK activator.

YLF466D activated recombinant human 111, 211 and rat liver AMPK. It also activated AMPK -subunit truncations containing an autoinhibitory domain(AID) and exhibited additivity with AMP and A-769662. Molecular docking of YLF466D with the S pombe AMPKa (25-351) suggests it may bind in the cleft between the kinase domain and the AID antagonizing the auto-inhibition distinct from AMP and A-769662. Incubation of YLF466D in Hela cells activated cellular AMPK without detectable changes in AMP:ATP ratio, proving AMPK was allosterically activated by YLF466D. YLF466D activated cellular AMPK in both L6 myotubes and HepG2 cells with evoking intracellular AMP:ATP ratio accompanied by depolarizing mitochondria membrane potential, but has no effect on the dephosphorylation of PP2C on AMPK. Thus, YLF466D activated cellular AMPK through dual mechanisms [1].

 

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