YL-109 has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo, which repressed the sphere-forming ability and the expression of stem cell markers in MDA-MB-231 mammosphere cultures. YL-109 increased the expression of carboxyl terminus of Hsp70-interacting protein (CHIP), which suppresses tumorigenic and metastatic potential of breast cancer cells by inhibiting the oncogenic pathway.
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化学信息
| 名称 | YL-109 |
| Iupac 化学名称 | InChI=1S/C14H11NO2S/c1-17-12-8-9(6-7-11(12)16)14-15-10-4-2-3-5-13(10)18-14/h2-8,15H,1H3 |
| 同义词 | YP109; YP 109 |
| 英文同义词 | YP109; YP 109 |
| 分子式 | C14H11NO2S |
| 分子量 | 257.31 |
| Smile | COC1=CC(C2=NC3=CC=CC=C3S2)=CC=C1O |
| InChiKey | KRVBOHJNAFQFPW-UHFFFAOYSA-N |
| InChi | InChI=1S/C14H11NO2S/c1-17-12-8-9(6-7-11(12)16)14-15-10-4-2-3-5-13(10)18-14/h2-8,16H,1H3 |
| Cas号 | 36341-25-0 |
| 相关CAS号 | |
| 外观性状 | Solid powder |
| 纯度 | 98% |
| 存储 | -20 ºC for 3 years |
| 可溶性 | Soluble in DMSO |
| 处理方式 | |
| 运输条件 | Shipped under ambient temperature |
| 海关编码 | |
| Targets | |
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study | |