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YHO-13351

Catalog No.: 6111512
Cas No.: 1346753-00-1
Purity : 98% 
6111512 - YHO-13351 | CAS 1346753-00-1

Catalog number : 6111512

CAS number : 1346753-00-1

分子式 : C27H37N3O7S2 

分子量 : 579.73 

Iupac 化学名称 : YHO-13351 

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分子式C27H37N3O7S2 
分子量579.73 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.


YHO-13351 was rapidly converted into YHO-13177 after its oral or intravenous administration. Coadministration of irinotecan with YHO-13351 significantly increased the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model, whereas irinotecan alone had little effect in these tumor models [1].



 

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