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XL388

Catalog No.: 161009016
Cas No.: 1251156-08-7
Purity : 98% by HPLC 
161009016 - XL388 | CAS 1251156-08-7

Catalog number : 161009016

CAS number : 1251156-08-7

分子式 : C23H22FN3O4S 

分子量 : 455.5 

Iupac 化学名称 : (7-(6-aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methylsulfonyl)phenyl)methanone 

Smile : NC1=CC=C(C=N1)C=1C=CC2=C(CN(CCO2)C(=O)C2=C(C(=C(C=C2)S(=O)(=O)C)F)C)C1

InChiKey : LNFBAYSBVQBKFR-UHFFFAOYSA-N

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同义词XL388; XL-388; XL 388. 
英文同义词XL388; XL-388; XL 388. 
分子式C23H22FN3O4S 
分子量455.5 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileNC1=CC=C(C=N1)C=1C=CC2=C(CN(CCO2)C(=O)C2=C(C(=C(C=C2)S(=O)(=O)C)F)C)C1
InChiKeyLNFBAYSBVQBKFR-UHFFFAOYSA-N
InChiInChI=1S/C23H22FN3O4S/c1-14-18(5-7-20(22(14)24)32(2,29)30)23(28)27-9-10-31-19-6-3-15(11-17(19)13-27)16-4-8-21(25)26-12-16/h3-8,11-12H,9-10,13H2,1-2H3,(H2,25,26)
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XL388 inhibited cellular phosphorylation of mTOR complex 1 (p-p70S6K, pS6, and p-4E-BP1) and mTOR complex 2 (pAKT (S473)) substrates. XL388 displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. Oral administration of XL388 to athymic nude mice implanted with human tumor xenografts afforded significant and dose-dependent antitumor activity. 

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