XL388
编号: 161009016
Cas号: 1251156-08-7
纯度: 98% by HPLC
XL388 inhibited cellular phosphorylation of mTOR complex 1 (p-p70S6K, pS6, and p-4E-BP1) and mTOR complex 2 (pAKT (S473)) substrates. XL388 displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. Oral administration of XL388 to athymic nude mice implanted with human tumor xenografts afforded significant and dose-dependent antitumor activity.
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化学信息
| 名称 | XL388 |
|---|---|
| Iupac 化学名称 | (7-(6-aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methylsulfonyl)phenyl)methanone |
| 同义词 | XL388; XL-388; XL 388. |
| 英文同义词 | XL388; XL-388; XL 388. |
| 分子式 | C23H22FN3O4S |
| 分子量 | 455.5 |
| Smile | NC1=CC=C(C=N1)C=1C=CC2=C(CN(CCO2)C(=O)C2=C(C(=C(C=C2)S(=O)(=O)C)F)C)C1 |
| InChiKey | LNFBAYSBVQBKFR-UHFFFAOYSA-N |
| InChi | InChI=1S/C23H22FN3O4S/c1-14-18(5-7-20(22(14)24)32(2,29)30)23(28)27-9-10-31-19-6-3-15(11-17(19)13-27)16-4-8-21(25)26-12-16/h3-8,11-12H,9-10,13H2,1-2H3,(H2,25,26) |
| Cas号 | 1251156-08-7 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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| 大货 | 询价 | 询价 | 询价 |
