Wortmannin
编号: 160926005
Cas号: 19545-26-7
纯度: 98% by HPLC
It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K. The half-life of wortmannin in tissue culture is about 10 minutes due to the presence of the highly reactive C20 carbon that is also responsible for its ability to covalently inactivate PI3K. Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation (http://en.wikipedia.org/wiki/Wortmannin).
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化学信息
| 名称 | Wortmannin |
|---|---|
| Iupac 化学名称 | (1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-3,6,6b,7,8,9,9a,10,11,11b-decahydro-1H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate. |
| 同义词 | Wortmannin; SL2052; SL-2052; SL 2052. |
| 英文同义词 | Wortmannin; SL2052; SL-2052; SL 2052. |
| 分子式 | C23H24O8 |
| 分子量 | 428.43 |
| Smile | CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@@]4(c5c(coc5C3=O)C(=O)O[C@@H]4COC)C)C |
| InChiKey | QDLHCMPXEPAAMD-QAIWCSMKSA-N |
| InChi | InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 |
| Cas号 | 19545-26-7 |
| MDL | MFCD00133927 |
| 相关CAS号 |
订购信息
| 包装 | 价格 | 库存 | 纯度 | 备货期 |
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