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Wortmannin

Catalog No.: 160926005
Cas No.: 19545-26-7
Purity : 98% by HPLC 
160926005 - Wortmannin | CAS 19545-26-7

Catalog number : 160926005

CAS number : 19545-26-7

分子式 : C23H24O8 

分子量 : 428.43 

Iupac 化学名称 : (1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-3,6,6b,7,8,9,9a,10,11,11b-decahydro-1H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate. 

Smile : CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@@]4(c5c(coc5C3=O)C(=O)O[C@@H]4COC)C)C

InChiKey : QDLHCMPXEPAAMD-QAIWCSMKSA-N

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同义词Wortmannin; SL2052; SL-2052; SL 2052. 
英文同义词Wortmannin; SL2052; SL-2052; SL 2052. 
分子式C23H24O8 
分子量428.43 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@@]4(c5c(coc5C3=O)C(=O)O[C@@H]4COC)C)C
InChiKeyQDLHCMPXEPAAMD-QAIWCSMKSA-N
InChiInChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
MDLMFCD00133927
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It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K. The half-life of wortmannin in tissue culture is about 10 minutes due to the presence of the highly reactive C20 carbon that is also responsible for its ability to covalently inactivate PI3K. Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation (http://en.wikipedia.org/wiki/Wortmannin). 

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