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WYE-125132

Catalog No.: 161009008
Cas No.: 1144068-46-1
Purity : 98% by HPLC 
161009008 - WYE-125132 | CAS 1144068-46-1

Catalog number : 161009008

CAS number : 1144068-46-1

分子式 : C27H33N7O4 

分子量 : 519.6 

Iupac 化学名称 : 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-methylurea 

Smile : C12CN(CC(CC1)O2)C2=C1C(=NC(=N2)C2=CC=C(C=C2)NC(=O)NC)N(N=C1)C1CCC2(OCCO2)CC1

InChiKey : QLHHRYZMBGPBJG-UHFFFAOYSA-N

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同义词WYE 125132; WYE-125132; WYE125132; WYE132; WYE 132�� WYE-132 
英文同义词WYE 125132; WYE-125132; WYE125132; WYE132; WYE 132�� WYE-132 
分子式C27H33N7O4 
分子量519.6 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileC12CN(CC(CC1)O2)C2=C1C(=NC(=N2)C2=CC=C(C=C2)NC(=O)NC)N(N=C1)C1CCC2(OCCO2)CC1
InChiKeyQLHHRYZMBGPBJG-UHFFFAOYSA-N
InChiInChI=1S/C27H33N7O4/c1-28-26(35)30-18-4-2-17(3-5-18)23-31-24(33-15-20-6-7-21(16-33)38-20)22-14-29-34(25(22)32-23)19-8-10-27(11-9-19)36-12-13-37-27/h2-5,14,19-21H,6-13,15-16H2,1H3,(H2,28,30,35)
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WYE-132 inhibited mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo. Importantly, consistent with genetic ablation of mTORC2, WYE-132 targeted P-AKT(S473) and AKT function without significantly reducing the steady-state level of the PI3K/PDK1 activity biomarker P-AKT(T308), highlighting a prominent and direct regulation of AKT by mTORC2 in cancer cells.  

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