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WDR5-0103

Catalog No.: 16122845
Cas No.: 890190-22-4
Purity : 98% 
16122845 - WDR5-0103 | CAS 890190-22-4

Catalog number : 16122845

CAS number : 890190-22-4

分子式 : C21H25N3O4 

分子量 : 383.448 

Iupac 化学名称 : WDR5-0103 

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同义词WDR 5-0103; WDR-5-0103; WDR50103; WDR-50103; WDR 50103; WD-Repeat Protein 5-0103 
英文同义词WDR 5-0103; WDR-5-0103; WDR50103; WDR-50103; WDR 50103; WD-Repeat Protein 5-0103 
分子式C21H25N3O4 
分子量383.448 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM), inhibiting the catalytic activity of the MLL core complex in vitro (IC50 = 39 M). WD repeat domain 5 (WDR5) plays an important role in various biological functions through the epigenetic regulation of gene transcription. WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis. 

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