Vesatolimod(GS-9620)
编号: 19529
Cas号: 1228585-88-3
纯度: 98% Min.
| Description | GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7. | |
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| Targets |
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| In vitro | GS-9620 potently inhibited viral replication in peripheral blood mononuclear cells(PBMCs), particularly when added 24 to 48 hours prior to HIV infection (EC50= 27 nM). Depletion of pDCs, but not other immune cell subsets from PBMC cultures, suppressed GS-9620 antiviral activity. | |
| In vivo | Short-term oral administration of GS-9620 provides long-term suppression of serum and liver HBV DNA. GS-9620 administration induces production of IFN-α and other cytokines and chemokines, and activates ISGs, natural killer cells, and lymphocyte subsets. Its treatment reduces viral DNA, Serum levels of HB surface antigen, HB e antigen and numbers of HBV antigen-positive hepatocytes while hepatocyte apoptosis increases. Currently, GS-9620 is under clinical evaluation for treating chronic HBV infection and for reducing latent reservoirs in virally-suppressed HIV-infected patients. |
仅供研究使用。 我们不向患者出售。
化学信息
| 名称 | Vesatolimod(GS-9620) |
|---|---|
| Iupac 化学名称 | 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one |
| 同义词 | GS-9620; GS 9620; GS9620; Vesatolimod |
| 英文同义词 | GS-9620; GS 9620; GS9620; Vesatolimod |
| 分子式 | C22H30N6O2 |
| 分子量 | 410.51 |
| Smile | O=C1NC2=C(N)N=C(OCCCC)N=C2N(CC3=CC=CC(CN4CCCC4)=C3)C1 |
| InChiKey | VFOKSTCIRGDTBR-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H30N6O2/c1-2-3-11-30-22-25-20(23)19-21(26-22)28(15-18(29)24-19)14-17-8-6-7-16(12-17)13-27-9-4-5-10-27/h6-8,12H,2-5,9-11,13-15H2,1H3,(H,24,29)(H2,23,25,26) |
| Cas号 | 1228585-88-3 |
| 相关CAS号 |
订购信息
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