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VLX1570

Catalog No.: 611932
Cas No.: 1431280-51-1
Purity : 98% 
611932 - VLX1570 | CAS 1431280-51-1

Catalog number : 611932

CAS number : 1431280-51-1

分子式 : C23H17F2N3O6 

分子量 : 469.39 

Iupac 化学名称 : VLX1570 

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同义词VLX 1570; VLX-1570 
英文同义词VLX 1570; VLX-1570 
分子式C23H17F2N3O6 
分子量469.39 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature as non-hazardous chemical. 
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VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM.

VLX1570 inhibits proteasome deubiqu-itinase activity and induces accumulation of high molecularweight  polyubiquitinated proteins in cells.
Knock-down of USP14 in multiple myeloma cells induces loss of cell viability
VLX1570 induces accumulation of polyubiquitin chains and elicits apoptosis of multiple myeloma cells
VLX1570 induces apoptosis and cell death of MM cells


 

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