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VE-822

Catalog No.: 51607
Cas No.: 1232416-25-9
Purity : 98% 
51607 - VE-822 | CAS 1232416-25-9

Catalog number : 51607

CAS number : 1232416-25-9

分子式 : C24H25N5O3S 

分子量 : 463.55 

Iupac 化学名称 : 2-Pyrazinamine, 3-[3-[4-[(methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]- 

Smile : CNCC1=CC=C(C=C1)C1=NOC(=C1)C=1C(=NC=C(N1)C1=CC=C(C=C1)S(=O)(=O)C(C)C)N

InChiKey : JZCWLJDSIRUGIN-UHFFFAOYSA-N

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同义词VE-822,VX-970;VE822;VE 822;Berzosertib; M6620; M-6620; M 6620;
英文同义词VE-822,VX-970;VE822;VE 822;Berzosertib; M6620; M-6620; M 6620;
分子式C24H25N5O3S 
分子量463.55 
外观黄色固体粉末
纯度98% 
可溶性可溶于DMSO;不溶于水
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
运输条件可在常温下运输
SmileCNCC1=CC=C(C=C1)C1=NOC(=C1)C=1C(=NC=C(N1)C1=CC=C(C=C1)S(=O)(=O)C(C)C)N
InChiKeyJZCWLJDSIRUGIN-UHFFFAOYSA-N
InChiInChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)
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VE-822(Berzosertib), an analogue of VE-821 with increased potency and selectivity against ATR, increased solubility and good pharmacokinetic properties was shown to potently radiosensitise pancreatic cancer cell lines in vitro.VE-822 was the first selective ATR inhibitor to enter clinical development, and is now known as VX-970. In a recent study, published by Vertex Pharmaceuticals, VX-970 (VE-822) was shown to markedly sensitise a panel of non-small cell lung cancer cell lines, but not normal cells, to multiple DNA damaging drugs, namely cisplatin, oxaliplatin, gemcitabine, etoposide and SN38, the active metabolite of irinotecan.

 

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