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乌苯美司

Catalog No.: 17030602
Cas No.: 58970-76-6
Purity : 98% 
17030602 - 乌苯美司 | CAS 58970-76-6

Catalog number : 17030602

CAS number : 58970-76-6

分子式 : C16H24N2O4 

分子量 : 308.378 

Iupac 化学名称 : ((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-L-leucine 

Smile : N[C@@H]([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)O)CC1=CC=CC=C1

InChiKey : VGGGPCQERPFHOB-RDBSUJKOSA-N

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同义词Ubenimex; NK 421; NK-421; NK421; Bestatin; NSC 265489 
英文同义词Ubenimex; NK 421; NK-421; NK421; Bestatin; NSC 265489 
分子式C16H24N2O4 
分子量308.378 
外观类白色至白色固体
纯度98% 
可溶性可溶于DMSO;不溶于水
存储短期可在0-4度保存,数天至数月;长期可在-20度保存三年。
运输条件可在常温下运输
SmileN[C@@H]([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)O)CC1=CC=CC=C1
InChiKeyVGGGPCQERPFHOB-RDBSUJKOSA-N
InChiInChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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Ubenimex, also known as NK 421 and Bestatin, is a CD13 inhibitor. Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism. Ubenimex synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells. 

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