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UNC0642

Catalog No.: 16071013
Cas No.: 1481677-78-4
Purity : 98% by HPLC 
16071013 - UNC0642 | CAS 1481677-78-4

Catalog number : 16071013

CAS number : 1481677-78-4

分子式 : C29H44F2N6O2 

分子量 : 546.7078 

Iupac 化学名称 : 2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine 

Smile : FC1(CCN(CC1)C1=NC2=CC(=C(C=C2C(=N1)NC1CCN(CC1)C(C)C)OC)OCCCN1CCCC1)F

InChiKey : RNAMYOYQYRYFQY-UHFFFAOYSA-N

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同义词UNC0642; UNC-0642 
英文同义词UNC0642; UNC-0642 
分子式C29H44F2N6O2 
分子量546.7078 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileFC1(CCN(CC1)C1=NC2=CC(=C(C=C2C(=N1)NC1CCN(CC1)C(C)C)OC)OCCCN1CCCC1)F
InChiKeyRNAMYOYQYRYFQY-UHFFFAOYSA-N
InChiInChI=1S/C29H44F2N6O2/c1-21(2)36-14-7-22(8-15-36)32-27-23-19-25(38-3)26(39-18-6-13-35-11-4-5-12-35)20-24(23)33-28(34-27)37-16-9-29(30,31)10-17-37/h19-22H,4-18H2,1-3H3,(H,32,33,34)
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UNC0642 is a potent, selective inhibitor of G9a/GLP with improved PK properties. UNC0642 exhibits an in vitro IC50 <15 nM with selectivity > 100-fold over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. In cells, UNC0642 results in a potent reduction of H3K9me2 in MDA MB231 cells with IC50 = 106 nM.  

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