UNC0642
编号: 16071013
Cas号: 1481677-78-4
纯度: 98% by HPLC
UNC0642 is a potent, selective inhibitor of G9a/GLP with improved PK properties. UNC0642 exhibits an in vitro IC50 <15 nM with selectivity > 100-fold over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. In cells, UNC0642 results in a potent reduction of H3K9me2 in MDA MB231 cells with IC50 = 106 nM.
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化学信息
| 名称 | UNC0642 |
|---|---|
| Iupac 化学名称 | 2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine |
| 同义词 | UNC0642; UNC-0642 |
| 英文同义词 | UNC0642; UNC-0642 |
| 分子式 | C29H44F2N6O2 |
| 分子量 | 546.7078 |
| Smile | FC1(CCN(CC1)C1=NC2=CC(=C(C=C2C(=N1)NC1CCN(CC1)C(C)C)OC)OCCCN1CCCC1)F |
| InChiKey | RNAMYOYQYRYFQY-UHFFFAOYSA-N |
| InChi | InChI=1S/C29H44F2N6O2/c1-21(2)36-14-7-22(8-15-36)32-27-23-19-25(38-3)26(39-18-6-13-35-11-4-5-12-35)20-24(23)33-28(34-27)37-16-9-29(30,31)10-17-37/h19-22H,4-18H2,1-3H3,(H,32,33,34) |
| Cas号 | 1481677-78-4 |
| 相关CAS号 |
订购信息
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| 大货 | 询价 | 询价 | 询价 |
