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UNC0638

Catalog No.: 82403
Cas No.: 1255580-76-7
Purity : 98% 
82403 - UNC0638 | CAS 1255580-76-7

Catalog number : 82403

CAS number : 1255580-76-7

分子式 : C30H47N5O2 

分子量 : 509.73 

Iupac 化学名称 : 2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine 

Smile : C1(CCCCC1)C1=NC2=CC(=C(C=C2C(=N1)NC1CCN(CC1)C(C)C)OC)OCCCN1CCCC1

InChiKey : QOECJCJVIMVJGX-UHFFFAOYSA-N

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同义词UNC 0638; UNC-0638 
英文同义词UNC 0638; UNC-0638 
分子式C30H47N5O2 
分子量509.73 
外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileC1(CCCCC1)C1=NC2=CC(=C(C=C2C(=N1)NC1CCN(CC1)C(C)C)OC)OCCCN1CCCC1
InChiKeyQOECJCJVIMVJGX-UHFFFAOYSA-N
InChiInChI=1S/C30H47N5O2/c1-22(2)35-17-12-24(13-18-35)31-30-25-20-27(36-3)28(37-19-9-16-34-14-7-8-15-34)21-26(25)32-29(33-30)23-10-5-4-6-11-23/h20-24H,4-19H2,1-3H3,(H,31,32,33)
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UNC0638 is an inhibitor of G9a and GLP with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 treatment of a variety of cell lines resulted in lower global H3K9me2 levels, equivalent to levels observed for small hairpin RNA knockdown of G9a and GLP with the functional potency of UNC0638 being well separated from its toxicity. 

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