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Triheptanoin

编号: 25113
Cas号: 620-67-7
纯度: 98% Min.

Triheptanoin is a fatty acid metabolic modulator potentially for treatment of fatty acid oxidation disorders and GLUT1.

仅供研究使用。 我们不向患者出售。

化学信息

名称Triheptanoin
Iupac 化学名称propane-1,2,3-triyl triheptanoate
同义词IND-106011; UX-007; IND106011; UX007; IND 106011; UX 007; Triheptanoin; Glycerol trienanthate
英文同义词IND-106011; UX-007; IND106011; UX007; IND 106011; UX 007; Triheptanoin; Glycerol trienanthate
分子式C24H44O6
分子量428.60
SmileCCCCCCC(OCC(OC(CCCCCC)=O)COC(CCCCCC)=O)=O
InChiKeyPJHKBYALYHRYSK-UHFFFAOYSA-N
InChiInChI=1S/C24H44O6/c1-4-7-10-13-16-22(25)28-19-21(30-24(27)18-15-12-9-6-3)20-29-23(26)17-14-11-8-5-2/h21H,4-20H2,1-3H3
Cas号620-67-7
相关CAS号

订购信息

包装价格库存纯度备货期
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Request Bulk Quote Download MSDS 电话 : +86-177 0271 9238   Email : sales@sun-shinechem.com
外观性状类白色固体
纯度98% Min.
存储 0-4℃,可保存几天到几周;-20℃,可保存 几个月。
可溶性溶于DMSO等有机溶剂
处理方式
运输条件可以在室温下进行运输。
海关编码
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Vockley J, Marsden D, McCracken E, DeWard S, Barone A, Hsu K, Kakkis E. Long-term major clinical outcomes in patients with long chain fatty acid oxidation disorders before and after transition to triheptanoin treatment--A retrospective chart review. Mol Genet Metab. 2015 Sep-Oct;116(1-2):53-60. doi: 10.1016/j.ymgme.2015.06.006. Review. Erratum in: Mol Genet Metab. 2015 Nov;116(3):221. PubMed PMID: 26116311; PubMed Central PMCID: PMC4561603.

2: Vockley J, Charrow J, Ganesh J, Eswara M, Diaz GA, McCracken E, Conway R, Enns GM, Starr J, Wang R, Abdenur JE, Sanchez-de-Toledo J, Marsden DL. Triheptanoin treatment in patients with pediatric cardiomyopathy associated with long chain-fatty acid oxidation disorders. Mol Genet Metab. 2016 Nov;119(3):223-231. doi: 10.1016/j.ymgme.2016.08.008. PubMed PMID: 27590926; PubMed Central PMCID: PMC5083220.

3: Schwarzkopf TM, Koch K, Klein J. Reduced severity of ischemic stroke and improvement of mitochondrial function after dietary treatment with the anaplerotic substance triheptanoin. Neuroscience. 2015 Aug 6;300:201-9. doi: 10.1016/j.neuroscience.2015.05.014. PubMed PMID: 25982559.

4: Nguyen TD, Shingu Y, Amorim PA, Schwarzer M, Doenst T. Triheptanoin Alleviates Ventricular Hypertrophy and Improves Myocardial Glucose Oxidation in Rats With Pressure Overload. J Card Fail. 2015 Nov;21(11):906-15. doi: 10.1016/j.cardfail.2015.07.009. PubMed PMID: 26209001.

5: Pascual JM, Liu P, Mao D, Kelly DI, Hernandez A, Sheng M, Good LB, Ma Q, Marin-Valencia I, Zhang X, Park JY, Hynan LS, Stavinoha P, Roe CR, Lu H. Triheptanoin for glucose transporter type I deficiency (G1D): modulation of human ictogenesis, cerebral metabolic rate, and cognitive indices by a food supplement. JAMA Neurol. 2014 Oct;71(10):1255-65. doi: 10.1001/jamaneurol.2014.1584. PubMed PMID: 25110966; PubMed Central PMCID: PMC4376124.

6: Adanyeguh IM, Rinaldi D, Henry PG, Caillet S, Valabregue R, Durr A, Mochel F. Triheptanoin improves brain energy metabolism in patients with Huntington disease. Neurology. 2015 Feb 3;84(5):490-5. doi: 10.1212/WNL.0000000000001214. PubMed PMID: 25568297; PubMed Central PMCID: PMC4336068.

7: Tefera TW, Wong Y, Barkl-Luke ME, Ngo ST, Thomas NK, McDonald TS, Borges K. Triheptanoin Protects Motor Neurons and Delays the Onset of Motor Symptoms in a Mouse Model of Amyotrophic Lateral Sclerosis. PLoS One. 2016 Aug 26;11(8):e0161816. doi: 10.1371/journal.pone.0161816. PubMed PMID: 27564703; PubMed Central PMCID: PMC5001695.

8: Kim TH, Borges K, Petrou S, Reid CA. Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy. Epilepsy Res. 2013 Jan;103(1):101-5. doi: 10.1016/j.eplepsyres.2012.09.016. PubMed PMID: 23196212.

9: Thomas NK, Willis S, Sweetman L, Borges K. Triheptanoin in acute mouse seizure models. Epilepsy Res. 2012 May;99(3):312-7. doi: 10.1016/j.eplepsyres.2011.12.013. PubMed PMID: 22260920.

10: Tucci S, Floegel U, Beermann F, Behringer S, Spiekerkoetter U. Triheptanoin: long-term effects in the very long-chain acyl-CoA dehydrogenase-deficient mouse. J Lipid Res. 2017 Jan;58(1):196-207. doi: 10.1194/jlr.M072033. PubMed PMID: 27884962; PubMed Central PMCID: PMC5234721.

11: Hadera MG, Smeland OB, McDonald TS, Tan KN, Sonnewald U, Borges K. Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy. J Neurochem. 2014 Apr;129(1):107-19. doi: 10.1111/jnc.12610. PubMed PMID: 24236946.

12: Mochel F, Hainque E, Gras D, Adanyeguh IM, Caillet S, Héron B, Roubertie A, Kaphan E, Valabregue R, Rinaldi D, Vuillaumier S, Schiffmann R, Ottolenghi C, Hogrel JY, Servais L, Roze E. Triheptanoin dramatically reduces paroxysmal motor disorder in patients with GLUT1 deficiency. J Neurol Neurosurg Psychiatry. 2016 May;87(5):550-3. doi: 10.1136/jnnp-2015-311475. PubMed PMID: 26536893; PubMed Central PMCID: PMC4853553.

13: Vieira de Melo IS, Da Rocha Ataide T, Lima de Oliveira S, Bezerra Bueno N, Duarte de Freitas J, Goulart Sant'Ana AE. HEPATIC FATTY ACID PROFILE OF RATS FED A TRIHEPTANOIN-BASED KETOGENIC DIET. Nutr Hosp. 2015 Jul 1;32(1):265-9. doi: 10.3305/nh.2015.32.1.9033. PubMed PMID: 26262726.

14: Breen C, White FJ, Scott CA, Heptinstall L, Walter JH, Jones SA, Morris AA. Unsuccessful treatment of severe pyruvate carboxylase deficiency with triheptanoin. Eur J Pediatr. 2014 Mar;173(3):361-6. doi: 10.1007/s00431-013-2166-5. PubMed PMID: 24114256.

15: Roe CR, Brunengraber H. Anaplerotic treatment of long-chain fat oxidation disorders with triheptanoin: Review of 15 years Experience. Mol Genet Metab. 2015 Dec;116(4):260-8. doi: 10.1016/j.ymgme.2015.10.005. PubMed PMID: 26547562; PubMed Central PMCID: PMC4712637.

16: Willis S, Stoll J, Sweetman L, Borges K. Anticonvulsant effects of a triheptanoin diet in two mouse chronic seizure models. Neurobiol Dis. 2010 Dec;40(3):565-72. doi: 10.1016/j.nbd.2010.07.017. PubMed PMID: 20691264; PubMed Central PMCID: PMC2955820.

17: Francis JS, Markov V, Leone P. Dietary triheptanoin rescues oligodendrocyte loss, dysmyelination and motor function in the nur7 mouse model of Canavan disease. J Inherit Metab Dis. 2014 May;37(3):369-81. doi: 10.1007/s10545-013-9663-6. PubMed PMID: 24288037.

18: Aso E, Semakova J, Joda L, Semak V, Halbaut L, Calpena A, Escolano C, Perales JC, Ferrer I. Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in APP/PS1 mice used as a model of familial Alzheimer's disease. Curr Alzheimer Res. 2013 Mar;10(3):290-7. PubMed PMID: 23131121.

19: Park MJ, Aja S, Li Q, Degano AL, Penati J, Zhuo J, Roe CR, Ronnett GV. Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice. PLoS One. 2014 Oct 9;9(10):e109527. doi: 10.1371/journal.pone.0109527. PubMed PMID: 25299635; PubMed Central PMCID: PMC4192301.

20: Hadera MG, McDonald T, Smeland OB, Meisingset TW, Eloqayli H, Jaradat S, Borges K, Sonnewald U. Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-L-Carnitine. Neurochem Res. 2016 Feb;41(1-2):86-95. doi: 10.1007/s11064-015-1728-5. Review. PubMed PMID: 26433381.

化学结构

25113 - Triheptanoin | CAS 620-67-7

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