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Triciribine

Catalog No.: 161009022
Cas No.: 35943-35-2
Purity : 98% by HPLC 
161009022 - Triciribine | CAS 35943-35-2

Catalog number : 161009022

CAS number : 35943-35-2

分子式 : C13H16N6O4 

分子量 : 320.3 

Iupac 化学名称 : (2R,3R,4S,5R)-2-(3-amino-5-methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol. 

Smile : CN1c2c3c(cn(c3ncn2)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)C(=N1)N

InChiKey : HOGVTUZUJGHKPL-HTVVRFAVSA-N

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同义词VQD002TCNPtriciribineTricyclic nucleoside; PentaazacentopthyleneAPI2Akt Inhibitor V. 
英文同义词VQD002TCNPtriciribineTricyclic nucleoside; PentaazacentopthyleneAPI2Akt Inhibitor V. 
分子式C13H16N6O4 
分子量320.3 
外观Solid powder 
纯度98% by HPLC 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileCN1c2c3c(cn(c3ncn2)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)C(=N1)N
InChiKeyHOGVTUZUJGHKPL-HTVVRFAVSA-N
InChiInChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1
MDLMFCD00932413
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Triciribine inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Akts are anti-apoptotic serine/theronine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and caspase 9. Check for active clinical trials or closed clinical trials using this agent. 

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