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Tretazicar (CB1954)

Catalog No.: 100906
Cas No.: 21919-05-1
Purity : 98% 
100906 - Tretazicar (CB1954) | CAS 21919-05-1

Catalog number : 100906

CAS number : 21919-05-1

分子式 : C9H8N4O5 

分子量 : 252.18 

Iupac 化学名称 : 5-(aziridin-1-yl)-2,4-dinitrobenzamide 

Smile : N1(CC1)C=1C(=CC(=C(C(=O)N)C1)[N+](=O)[O-])[N+](=O)[O-]

InChiKey : WOCXQMCIOTUMJV-UHFFFAOYSA-N

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同义词CB-1954; CB 1954 
英文同义词CB-1954; CB 1954 
分子式C9H8N4O5 
分子量252.18 
外观Solid powder 
纯度98% 
可溶性Soluble in DMSO 
存储-20 ºC for 3 years 
运输条件Shipped under ambient temperature 
SmileN1(CC1)C=1C(=CC(=C(C(=O)N)C1)[N+](=O)[O-])[N+](=O)[O-]
InChiKeyWOCXQMCIOTUMJV-UHFFFAOYSA-N
InChiInChI=1S/C9H8N4O5/c10-9(14)5-3-7(11-1-2-11)8(13(17)18)4-6(5)12(15)16/h3-4H,1-2H2,(H2,10,14)
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Tretazicar is a dinitrobenzamide prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide into a potent cytotoxic bifunctional alkylating agent. CB1954 has been proposed for use in enzyme-prodrug gene therapy systems with the Escherichia coli enzyme nitroreductase (Ntr). Ntr converts CB1954 to 2- and 4-hydroxylamino derivatives, whereupon the non-enzymatic reaction of the 4-hydroxylamino derivative with cellular thio- esters generates a potent cytotoxic bifunctional alkylating agent capable of cross-linking DNA.
 

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