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Trametinib (GSK1120212)

Catalog No.: 52109
Cas No.: 871700-17-3
Purity : 98% 
52109 - Trametinib (GSK1120212) | CAS 871700-17-3

Catalog number : 52109

CAS number : 871700-17-3

分子式 : C26H23FIN5O4 

分子量 : 615.39 

Iupac 化学名称 : N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide 

Smile : C1(CC1)N1C(N(C=2C(C1=O)=C(N(C(C2C)=O)C)NC2=C(C=C(C=C2)I)F)C=2C=C(C=CC2)NC(C)=O)=O

InChiKey : LIRYPHYGHXZJBZ-UHFFFAOYSA-N

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同义词Trametinib,GSK1120212 
英文同义词Trametinib,GSK1120212 
分子式C26H23FIN5O4 
分子量615.39 
外观off-white solid 
纯度98% 
可溶性5mg/ml in DMSO 
存储3 years -20ºCpowder 6 months-80ºCin solvent 
运输条件Shipped under ambient temperature 
SmileC1(CC1)N1C(N(C=2C(C1=O)=C(N(C(C2C)=O)C)NC2=C(C=C(C=C2)I)F)C=2C=C(C=CC2)NC(C)=O)=O
InChiKeyLIRYPHYGHXZJBZ-UHFFFAOYSA-N
InChiInChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
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Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. 

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