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Torin 2

Catalog No.: 52311
Cas No.: 1223001-51-1
Purity : 98% 
52311 - Torin 2 | CAS 1223001-51-1

Catalog number : 52311

CAS number : 1223001-51-1

分子式 : C24H15F3N4O 

分子量 : 432.4 

Iupac 化学名称 : 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one 

Smile : O=C1N(C2=CC=CC(C(F)(F)F)=C2)C3=C(C=NC4=CC=C(C5=CC=C(N)N=C5)C=C43)C=C1

InChiKey : GUXXEUUYCAYESJ-UHFFFAOYSA-N

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同义词N/A 
英文同义词N/A 
分子式C24H15F3N4O 
分子量432.4 
外观crystalline solid 
纯度98% 
可溶性Soluble in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature 
SmileO=C1N(C2=CC=CC(C(F)(F)F)=C2)C3=C(C=NC4=CC=C(C5=CC=C(N)N=C5)C=C43)C=C1
InChiKeyGUXXEUUYCAYESJ-UHFFFAOYSA-N
InChiInChI=1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)
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Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively. 

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